Interleukin-5 in the pathophysiology of severe asthma
C Pelaia, G Paoletti, F Puggioni, F Racca… - Frontiers in …, 2019 - frontiersin.org
Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival,
and degranulation of eosinophils. Indeed, during the last years, significant advances have …
and degranulation of eosinophils. Indeed, during the last years, significant advances have …
Eosinophilic esophagitis: Immune mechanisms and therapeutic targets
D Khokhar, S Marella, G Idelman… - Clinical & …, 2022 - Wiley Online Library
Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease of the
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …
Anti‐KIT monoclonal antibody CDX‐0159 induces profound and durable mast cell suppression in a healthy volunteer study
D Alvarado, M Maurer, R Gedrich, SB Seibel… - Allergy, 2022 - Wiley Online Library
Background Mast cells (MC) are powerful inflammatory immune sentinel cells that drive
numerous allergic, inflammatory, and pruritic disorders when activated. MC‐targeted …
numerous allergic, inflammatory, and pruritic disorders when activated. MC‐targeted …
One year of mepolizumab. Efficacy and safety in real-life in Italy
D Bagnasco, M Caminati, F Menzella… - Pulmonary …, 2019 - Elsevier
Background Severe asthma is a disease with a heavy socio-economic burden and a
relevant impact on the life of patients. Mepolizumab (MEP) was recently introduced in …
relevant impact on the life of patients. Mepolizumab (MEP) was recently introduced in …
Holy Grail: the journey towards disease modification in asthma
WW Busse, E Melén… - European Respiratory …, 2022 - Eur Respiratory Soc
At present, there is no cure for asthma, and treatment typically involves therapies that
prevent or reduce asthma symptoms, without modifying the underlying disease. A “disease …
prevent or reduce asthma symptoms, without modifying the underlying disease. A “disease …
[HTML][HTML] Efficacy of Benralizumab in severe asthma in real life and focus on nasal polyposis
D Bagnasco, L Brussino, M Bonavia, E Calzolari… - Respiratory …, 2020 - Elsevier
Introduction Severe asthma occurs in 5–10% of asthmatic patients, with nasal polyposis as
one of the most frequent comorbidity. Benralizumab was recently marketed, thus we could …
one of the most frequent comorbidity. Benralizumab was recently marketed, thus we could …
Biologics in severe asthma: the role of real-world evidence from registries
G Paoletti, J Pepys, M Casini, D Di Bona… - European …, 2022 - Eur Respiratory Soc
Asthma is one of the most common noncommunicable diseases; in the majority of patients it
is well controlled with inhaled bronchodilators and inhaled corticosteroids, but the …
is well controlled with inhaled bronchodilators and inhaled corticosteroids, but the …
Targeted therapy for severe asthma in children and adolescents: current and future perspectives
A Licari, S Manti, R Castagnoli, GF Parisi, C Salpietro… - Pediatric Drugs, 2019 - Springer
Severe asthma in children remains a significant issue. It places a heavy burden on affected
individuals and society as a whole in terms of high morbidity, mortality, consumption of …
individuals and society as a whole in terms of high morbidity, mortality, consumption of …
Regulatory T cells mediated immunomodulation during asthma: a therapeutic standpoint
MA Khan - Journal of translational medicine, 2020 - Springer
Asthma is an inflammatory disease of the lung airway network, which is initiated and
perpetuated by allergen-specific CD4+ T cells, IgE antibodies, and a massive release of Th2 …
perpetuated by allergen-specific CD4+ T cells, IgE antibodies, and a massive release of Th2 …
Pharmacological induction of granulocyte cell death as therapeutic strategy
T Kaufmann, HU Simon - Annual review of pharmacology and …, 2023 - annualreviews.org
Apoptosis is central for the maintenance of health. In the immune system, apoptosis
guarantees proper development of immune cells and shutdown of immune reactions by the …
guarantees proper development of immune cells and shutdown of immune reactions by the …