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Autophagy and cardiac diseases: Therapeutic potential of natural products
The global incidence of cardiac diseases is expected to increase in the coming years,
imposing a substantial socioeconomic burden on healthcare systems. Autophagy is a tightly …
imposing a substantial socioeconomic burden on healthcare systems. Autophagy is a tightly …
Induced pluripotent stem cells: at the heart of cardiovascular precision medicine
The advent of human induced pluripotent stem cell (hiPSC) technology has revitalized the
efforts in the past decade to realize more fully the potential of human embryonic stem cells …
efforts in the past decade to realize more fully the potential of human embryonic stem cells …
Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …
understanding of how these disorders originate is limited by our ability to model the human …
Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells
Chromatin architecture has been implicated in cell type-specific gene regulatory programs,
yet how chromatin remodels during development remains to be fully elucidated. Here, by …
yet how chromatin remodels during development remains to be fully elucidated. Here, by …
Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow
It has been known for some time that atherosclerotic lesions preferentially develop in areas
exposed to low SS and are characterized by a proinflammatory, apoptotic, and senescent …
exposed to low SS and are characterized by a proinflammatory, apoptotic, and senescent …
Cellular metabolism and induced pluripotency
The discovery of induced pluripotent stem cells (iPSCs) a decade ago, which we are
celebrating in this issue of Cell, represents a landmark discovery in biomedical research …
celebrating in this issue of Cell, represents a landmark discovery in biomedical research …
[HTML][HTML] Mechanisms of mitochondrial dysfunction in lysosomal storage disorders: a review
Mitochondrial dysfunction is emerging as an important contributory factor to the
pathophysiology of lysosomal storage disorders (LSDs). The cause of mitochondrial …
pathophysiology of lysosomal storage disorders (LSDs). The cause of mitochondrial …
Biology of the cardiac myocyte in heart disease
Cardiac hypertrophy is a major risk factor for heart failure, and it has been shown that this
increase in size occurs at the level of the cardiac myocyte. Cardiac myocyte model systems …
increase in size occurs at the level of the cardiac myocyte. Cardiac myocyte model systems …
[HTML][HTML] Regulation of endogenous cardiomyocyte proliferation: The known unknowns
Myocardial regeneration in patients with cardiac damage is a long-sought goal of clinical
medicine. In animal species in which regeneration occurs spontaneously, as well as in …
medicine. In animal species in which regeneration occurs spontaneously, as well as in …
LAMP-2B regulates human cardiomyocyte function by mediating autophagosome–lysosome fusion
Mutations in lysosomal-associated membrane protein 2 (LAMP-2) gene are associated with
Danon disease, which often leads to cardiomyopathy/heart failure through poorly defined …
Danon disease, which often leads to cardiomyopathy/heart failure through poorly defined …