Shortcomings related to the treatment of bone diseases and consequent tissue regeneration
such as transplants have been addressed to some extent by tissue engineering and …

Fracture healing is a critically important clinical event for fracture patients and for clinicians
who take care of them. The clinical evaluation of fracture healing is based on both …

Background and purpose—Fracture non-union remains a major clinical problem, yet there
are no data available regarding the overall risk of fractures progressing to non-union in a …

Background Tibia shaft fractures (TSF) are common for men and women and cause
substantial morbidity, healthcare use, and costs. The impact of nonunions on healthcare use …

Non-union of bone following fracture is an orthopaedic condition with a high morbidity and
clinical burden. Despite its estimated global prevalence of nine million annually, the limit of …

Growth factors are very promising molecules to enhance bone regeneration. However, their
translation to clinical use has been seriously limited, facing issues related to safety and cost …

Delivery of recombinant proteins is a proven therapeutic strategy to promote endogenous
repair mechanisms and tissue regeneration. Bone morphogenetic protein-2 (rhBMP-2) has …

Over the past several decades, recombinant human bone morphogenetic proteins (rhBMPs)
have been the most extensively studied and widely used osteoinductive agents for clinical …

Purpose This review evaluates the application of bone morphogenetic proteins (BMPs) in
delayed bone repair, aiming at a broad audience from clinicians to scientists. Next to an …

Determining whether a bone fracture is healed is one of the most important and fundamental
clinical determinations made in orthopaedics. However, there are currently no standardized …