Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

Pruritus in cholestatic liver diseases can be a major burden and dramatically impair the
quality of life of those affected. Here, we provide an update on the latest insights into the …

Crosstalk between ion channels and small GTPases is critical during homeostasis and
disease, but little is known about the structural underpinnings of these interactions. TRPV4 is …

Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that
affects people of all ages. It is characterized by chronic eczema, constant pruritus, and …

Transient Receptor Potential (TRP) channels are multifunctional sensory molecules that are
abundant in the skin and are involved in the sensory pathways of itch, pain, and …

The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …

Polyunsaturated fatty acids (PUFAs) are dietary components participating in
neurotransmission and cell signaling. Pollen is a source of PUFAs for honeybees, and …

Our understanding of neuropathic itch is limited due to a lack of relevant animal models.
Patients with cutaneous T cell lymphoma (CTCL) experience severe itching. Here, we …

Abstract TMEM16F, a Ca 2+-activated phospholipid scramblase (CaPLSase), is critical for
placental trophoblast syncytialization, HIV infection, and SARS-CoV2-mediated …