The IGF‐1 receptor in cancer biology
R Baserga, F Peruzzi, K Reiss - International journal of cancer, 2003 - Wiley Online Library
The type 1 insulin‐like growth factor receptor (IGF‐1R) plays an important role in the
establishment and maintenance of the transformed phenotype. It also has a strong …
establishment and maintenance of the transformed phenotype. It also has a strong …
[HTML][HTML] IGF1R signalling and its inhibition
J Riedemann, VM Macaulay - Endocrine-related cancer, 2006 - erc.bioscientifica.com
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently
overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF …
overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF …
Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells
The insulin receptor substrate-1 (IRS-1), a docking protein for both the type 1 insulin-like
growth factor receptor (IGF-IR) and the insulin receptor, is known to send a mitogenic, anti …
growth factor receptor (IGF-IR) and the insulin receptor, is known to send a mitogenic, anti …
[HTML][HTML] IGF-I receptor signalling in transformation and differentiation
B Valentinis, R Baserga - Molecular Pathology, 2001 - ncbi.nlm.nih.gov
The type 1 insulin-like growth factor receptor (IGF-IR) sends several signals, some of which
are contradictory. When the concentrations of insulin receptor substrate 1 (IRS-1), a major …
are contradictory. When the concentrations of insulin receptor substrate 1 (IRS-1), a major …
Antimyeloma activity of heat shock protein-90 inhibition
We show that multiple myeloma (MM), the second most commonly diagnosed hematologic
malignancy, is responsive to hsp90 inhibitors in vitro and in a clinically relevant orthotopic in …
malignancy, is responsive to hsp90 inhibitors in vitro and in a clinically relevant orthotopic in …
Insulin receptor substrate (IRS) transduction system: distinct and overlap** signaling potential
B Giovannone, M Lucia Scaldaferri… - Diabetes/metabolism …, 2000 - Wiley Online Library
Insulin receptor substrate (IRS) proteins play a central role in maintaining basic cellular
functions such as growth and metabolism. They act as an interface between multiple growth …
functions such as growth and metabolism. They act as an interface between multiple growth …
The regulation of adipocyte growth in white adipose tissue
Q Li, KL Spalding - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Adipocytes can increase in volume up to a thousand-fold, storing excess calories as
triacylglycerol in large lipid droplets. The dramatic morphological changes required of …
triacylglycerol in large lipid droplets. The dramatic morphological changes required of …
The insulin-like growth factor-I receptor as a target for cancer therapy
R Baserga - Expert opinion on therapeutic targets, 2005 - Taylor & Francis
This review examines the rationale for targeting the insulin-like growth factor (IGF)-I receptor
in the therapy of human tumours and their metastases. The rationale is based on two crucial …
in the therapy of human tumours and their metastases. The rationale is based on two crucial …
Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation
The insulin-like growth factor 1 receptor (IGF-1R) is a multifunctional receptor that mediates
signals for cell proliferation, differentiation, and survival. Genetic experiments showed that …
signals for cell proliferation, differentiation, and survival. Genetic experiments showed that …
Diabetes induces apoptosis in lymphocytes
Transgenic CBA mice expressing either the tyrosine kinase GTK (gut tyrosine kinase) or the
adaptor protein SHB (Src homology 2 protein of beta-cells) under the control of the rat …
adaptor protein SHB (Src homology 2 protein of beta-cells) under the control of the rat …