The Long COVID/Post Acute Sequelae of COVID-19 (PASC) group includes patients with
initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is …

Chronic pain is a critical clinical problem with an increasing prevalence. However, there are
limited effective prevention measures and treatments for chronic pain. Astrocytes are the …

The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been
widely demonstrated that neuroinflammation plays a critical role in the development of …

Diabetic neuropathy, with its major clinical sequels, notably neuropathic pain, foot ulcers,
and autonomic dysfunction, is associated with substantial morbidity, increased risk of …

Neuropathic pain, a maladaptive and chronic condition that can develop after a lesion or
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …

The increasing number of individuals with comorbidities poses an urgent need to improve
the management of patients with multiple co-existing diseases. Among these comorbidities …

Background Saponins are glycosides which, after acid hydrolysis, liberate sugar (s) and an
aglycone (sapogenin) which can be triterpenoid or steroidal in nature. Steroidal saponins …

Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain are
challenging complications of cancer treatment. Many of the major classes of …