Iron accumulation is a cardinal feature of degenerating regions in the Parkinson's disease
brain. As a potent pro-oxidant, redox-active iron may be a key player in upstream …

Iron accumulation and neuroinflammation are pathological conditions found in several
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …

Inflammation and iron accumulation are present in a variety of neurodegenerative diseases
that include Alzheimer's disease and Parkinson's disease. The study of the putative …

Sepsis is a life-threatening condition caused by a dysregulated host-response to
inflammation, although it currently lacks a fully elucidated pathobiology. Iron is a crucial …

Iron is an essential molecule for biological processes, but its accumulation can lead to
oxidative stress and cellular death. Due to its oxidative effects, iron accumulation is …

Iron is an essential element in our daily diet. Most iron is required for the de novo synthesis
of red blood cells, where it plays a critical role in oxygen binding to hemoglobin. Thus, iron …

Brain iron is a crucial participant and regulator of normal physiological activity. However,
excess iron is involved in the formation of free radicals, and has been associated with …

Background The National NeuroAIDS Tissue Consortium (NNTC) performed a brain gene
expression array to elucidate pathophysiologies of Human Immunodeficiency Virus type 1 …

Hepcidin is emerging as a new important factor in brain iron homeostasis. Studies suggest
that there are two sources of hepcidin in the brain; one is local and the other comes from the …

Inflammatory responses involving microglia and astrocytes contribute to the pathogenesis of
neurodegenerative diseases (NDs). In addition, inflammation is tightly linked to iron …