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PROTAC: an effective targeted protein degradation strategy for cancer therapy
Proteolysis targeting chimeric (PROTAC) technology is an effective endogenous protein
degradation tool developed in recent years that can ubiquitinate the target proteins through …
degradation tool developed in recent years that can ubiquitinate the target proteins through …
[HTML][HTML] A comprehensive analysis and anti-cancer activities of quercetin in ROS-mediated cancer and cancer stem cells
Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations,
activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation …
activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation …
[HTML][HTML] Therapeutics targeting p53-MDM2 interaction to induce cancer cell death
N Koo, AK Sharma, S Narayan - International journal of molecular …, 2022 - mdpi.com
Named as the guardian of the genome, p53 is a tumor suppressor that regulates cell
function, often through many different mechanisms such as DNA repair, apoptosis, cell cycle …
function, often through many different mechanisms such as DNA repair, apoptosis, cell cycle …
Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update
The presence of multidrug resistance (MDR) in malignant tumors is one of the primary
causes of treatment failure in cancer chemotherapy. The overexpression of the ATP binding …
causes of treatment failure in cancer chemotherapy. The overexpression of the ATP binding …
Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling
SC Koeberle, AP Kipp, H Stuppner… - Medicinal Research …, 2023 - Wiley Online Library
Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid
peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight …
peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight …
Creating and screening natural product libraries
Covering: up to 2020 The National Cancer Institute of the United States (NCI) has initiated a
Cancer Moonshot program entitled the NCI Program for Natural Product Discovery. As part …
Cancer Moonshot program entitled the NCI Program for Natural Product Discovery. As part …
The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities
Globally, prostate cancer (PCa) is regarded as a challenging health issue, and the number
of PCa patients continues to rise despite the availability of effective treatments in recent …
of PCa patients continues to rise despite the availability of effective treatments in recent …
Remodeling tumor microenvironment with natural products to overcome drug resistance
W Zhang, S Li, C Li, T Li, Y Huang - Frontiers in immunology, 2022 - frontiersin.org
With cancer incidence rates continuing to increase and occurrence of resistance in drug
treatment, there is a pressing demand to find safer and more effective anticancer strategy for …
treatment, there is a pressing demand to find safer and more effective anticancer strategy for …
Targeting USP7-mediated deubiquitination of MDM2/MDMX-p53 pathway for cancer therapy: are we there yet?
SM Qi, G Cheng, XD Cheng, Z Xu, B Xu… - Frontiers in cell and …, 2020 - frontiersin.org
The p53 tumor suppressor protein and its major negative regulators MDM2 and MDMX
oncoproteins form the MDM2/MDMX-p53 circuitry, which plays critical roles in regulating …
oncoproteins form the MDM2/MDMX-p53 circuitry, which plays critical roles in regulating …
p53 modulation of autophagy signaling in cancer therapies: perspectives mechanism and therapeutic targets
The key tumor suppressor protein p53, additionally known as p53, represents an attractive
target for the development and management of anti-cancer therapies. p53 has been …
target for the development and management of anti-cancer therapies. p53 has been …