Duchenne muscular dystrophy (DMD) is a severe, progressive, and incurable X-linked
disorder caused by mutations in the dystrophin gene. Patients with DMD have an absence of …

Nonsense suppression therapy encompasses approaches aimed at suppressing translation
termination at in-frame premature termination codons (PTCs, also known as nonsense …

Analyzing the type and frequency of patient‐specific mutations that give rise to Duchenne
muscular dystrophy (DMD) is an invaluable tool for diagnostics, basic scientific research …

Nonsense mutations promote premature translational termination and cause anywhere from
5–70% of the individual cases of most inherited diseases. Studies on nonsense-mediated …

Termination of protein synthesis is not 100% efficient. A number of natural mechanisms that
suppress translation termination exist. One of them is STOP codon readthrough, the process …

Approximately 10% of all pathological mutations are nonsense mutations that are
responsible for several severe genetic diseases for which no treatment regimens are …

Stop codon readthrough is used extensively by viruses to expand their gene expression.
Until recent discoveries in Drosophila, only a very limited number of readthrough cases in …

UMD–DMD France is a knowledgebase developed through a multicenter academic effort to
provide an up‐to‐date resource of curated information covering all identified mutations in …

Cryptic MHC I-associated peptides (MAPs) are produced via two mechanisms: translation of
protein-coding genes in non-canonical reading frames and translation of allegedly non …

Objective The objective of this study was to establish the feasibility of long‐term gentamicin
dosing to achieve stop codon readthrough and produce full‐length dystrophin. Mutation …