Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic

JE Butler, KM Lager, W Golde, KS Faaberg… - Immunologic …, 2014 - Springer
Porcine reproductive and respiratory disease syndrome (PRRS) is a viral pandemic that
especially affects neonates within the “critical window” of immunological development …

Mechanisms of adaptive immunity to porcine reproductive and respiratory syndrome virus

MC Rahe, MP Murtaugh - Viruses, 2017 - mdpi.com
The adaptive immune response is necessary for the development of protective immunity
against infectious diseases. Porcine reproductive and respiratory syndrome virus (PRRSV) …

Arterivirus minor envelope proteins are a major determinant of viral tropism in cell culture

D Tian, Z Wei, JC Zevenhoven-Dobbe, R Liu… - Journal of …, 2012 - Am Soc Microbiol
Arteriviruses are enveloped positive-strand RNA viruses for which the attachment proteins
and cellular receptors have remained largely controversial. Arterivirus particles contain at …

Host miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by upregulating type I interferons

L Li, Z Wei, Y Zhou, F Gao, Y Jiang, L Yu, H Zheng… - Virus research, 2015 - Elsevier
MicroRNAs (miRNAs) play important roles in viral infections, especially by modulating the
expression of cellular factors essential to viral replication or the host innate immune …

N-Linked Glycosylation of GP5 of Porcine Reproductive and Respiratory Syndrome Virus Is Critically Important for Virus Replication In Vivo

Z Wei, T Lin, L Sun, Y Li, X Wang, F Gao, R Liu… - Journal of …, 2012 - Am Soc Microbiol
It has been proposed that the N-linked glycan addition at certain sites in GP5 of porcine
reproductive and respiratory syndrome virus (PRRSV) is important for production of …

Engineering the PRRS virus genome: Updates and perspectives

M Han, D Yoo - Veterinary microbiology, 2014 - Elsevier
Porcine reproductive and respiratory syndrome virus (PRRSV) is endemic in most pig
producing countries worldwide and causes enormous economic losses to the pork industry …

Cellular miR-130b inhibits replication of porcine reproductive and respiratory syndrome virus in vitro and in vivo

L Li, F Gao, Y Jiang, L Yu, Y Zhou, H Zheng, W Tong… - Scientific reports, 2015 - nature.com
MicroRNAs (miRNAs) can impact viral infections by binding to sequences with partial
complementarity on viral RNA transcripts, usually resulting in the repression of virus …

Porcine reproductive and respiratory syndrome virus ORF5a protein is essential for virus viability

L Sun, Y Li, R Liu, X Wang, F Gao, T Lin, T Huang… - Virus research, 2013 - Elsevier
It has been shown that ORF5a protein in EAV is important but not essential for virus
infectivity. In this study, we found that RNA changes in the overlap** region (1–104 …

Generation of a porcine reproductive and respiratory syndrome virus expressing a marker gene inserted between ORF4 and ORF5a

Y Wang, W He, Q Li, X **e, N Qin, H Wang, J Huang… - Archives of …, 2020 - Springer
In recent years, the availability of reverse genetics systems for porcine reproductive and
respiratory syndrome virus (PRRSV) has created new perspectives for the use of …

The NN non-covalent domain of the nucleocapsid protein of type 2 porcine reproductive and respiratory syndrome virus enhances induction of IL-10 expression

X Liu, B Fan, J Bai, H Wang, Y Li… - Journal of General …, 2015 - microbiologyresearch.org
Porcine reproductive and respiratory syndrome virus (PRRSV) usually establishes a
prolonged infection and causes an immunosuppressive state. It has been proposed that IL …