Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

MicroRNAs (miRNAs) represent an important class of small regulatory RNAs that control
gene expression posttranscriptionally by targeting mRNAs for degradation or translation …

Acetylcholine (ACh) has been the first molecule to be identified as neurotransmitter. The
cholinergic and cholinoceptive areas, both in central and peripheral nervous system, have …

Background MicroRNAs (miRNAs) are small non-coding RNAs that recognize sites of
complementarity of target messenger RNAs, resulting in transcriptional regulation and …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
a CAG expansion in the gene-encoding Huntingtin (HTT). Transcriptome dysregulation is a …

Aging is the universal, intrinsic, genetically-controlled, evolutionarily-conserved and time-
dependent intricate biological process characterised by the cumulative decline in the …

Transcriptional dysregulation has long been recognized as central to the pathogenesis of
Huntington's disease (HD). MicroRNAs (miRNAs) represent a major system of post …

Huntington's disease (HD) is a debilitating neurodegenerative genetic disorder caused by
an expanded polyglutamine-coding (CAG) trinucleotide repeat in the huntingtin (HTT) gene …

Neurodegenerative disorders (NDD) have grabbed significant scientific consideration due to
their fast increase in prevalence worldwide. The specific pathophysiology of the disease and …

Transcriptional dysregulation in Huntington's disease (HD) is an early event that shapes the
brain transcriptome by both the depletion and ectopic activation of gene products that …