Methods of model reduction for large-scale biological systems: a survey of current methods and trends

TJ Snowden, PH van der Graaf, MJ Tindall - Bulletin of mathematical …, 2017 - Springer
Complex models of biochemical reaction systems have become increasingly common in the
systems biology literature. The complexity of such models can present a number of …

[PDF][PDF] Moving from postdictive to predictive kinetics in reaction engineering

WH Green - 2020 - dspace.mit.edu
Accurate quantitative chemical kinetic models are useful in many applications, ranging from
design of chemical processes to building a consensus for international treaties (eg the …

Dynamics and control of an ethyl acetate reactive distillation column

N Vora, P Daoutidis - Industrial & engineering chemistry research, 2001 - ACS Publications
In this paper, we study the dynamics and control of a reactive distillation column for the
production of ethyl acetate from acetic acid and ethyl alcohol. Initially, we propose a …

Experimental design and model reduction in systems biology

JE Jeong, Q Zhuang, MK Transtrum… - Quantitative …, 2018 - Wiley Online Library
Background In systems biology, the dynamics of biological networks are often modeled with
ordinary differential equations (ODEs) that encode interacting components in the systems …

Modelling the impact of mass transport in a miniplant photoreactor

F Gaulhofer, H Becker, A Peschl… - Reaction Chemistry & …, 2024 - pubs.rsc.org
The scale-up of photoreactions posses challenges due to the non-linear coupling of the
radiation field with reaction kinetics and mass transport. A knowledge-based scale-up …

Direct olivine carbonation: Optimal process design for a low-emission and cost-efficient cement production

AM Bremen, T Strunge, H Ostovari… - Industrial & …, 2022 - ACS Publications
Employing mineral carbonation products as a cementitious substitute could reduce the
cement industry's greenhouse gas (GHG) emissions. However, a transition toward low …

Algorithmic criteria for the validity of quasi-steady state and partial equilibrium models: The Michaelis–Menten reaction mechanism

DG Patsatzis, DA Goussis - Journal of Mathematical Biology, 2023 - Springer
We present “on the fly” algorithmic criteria for the accuracy and stability (non-stiffness) of
reduced models constructed with the quasi-steady state and partial equilibrium …

Extents of reaction and flow for homogeneous reaction systems with inlet and outlet streams

M Amrhein, N Bhatt, B Srinivasan, D Bonvin - AIChE journal, 2010 - Wiley Online Library
For homogeneous reaction systems with inlet and outlet streams, this article proposes a
linear transformation of the number of moles vector into three distinct parts, namely, the …

Non-linear reduction for kinetic models of metabolic reaction networks

ZP Gerdtzen, P Daoutidis, WS Hu - Metabolic engineering, 2004 - Elsevier
Kinetic models of metabolic networks are essential for predicting and optimizing the
transient behavior of cells in culture. However, such models are inherently high dimensional …

Asymptotology of chemical reaction networks

AN Gorban, O Radulescu, AY Zinovyev - Chemical Engineering Science, 2010 - Elsevier
The concept of the limiting step is extended to the asymptotology of multiscale reaction
networks. Complete theory for linear networks with well separated reaction rate constants is …