Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
Tau post-translational modifications: dynamic transformers of tau function, degradation, and aggregation
Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …
protein function and contributing to neurodegeneration. The explosion of information on …
Roles of tau protein in health and disease
Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …
Phosphorylated tau interactome in the human Alzheimer's disease brain
Accumulation of phosphorylated tau is a key pathological feature of Alzheimer's disease.
Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and …
Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and …
Ubiquitination in disease pathogenesis and treatment
D Popovic, D Vucic, I Dikic - Nature medicine, 2014 - nature.com
Ubiquitination is crucial for a plethora of physiological processes, including cell survival and
differentiation and innate and adaptive immunity. In recent years, considerable progress has …
differentiation and innate and adaptive immunity. In recent years, considerable progress has …
[HTML][HTML] Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
Alzheimer's Disease (AD) is a chronic neurodegenerative disorder and the most common
type of dementia (60–80% of cases). In 2016, nearly 44 million people were affected by AD …
type of dementia (60–80% of cases). In 2016, nearly 44 million people were affected by AD …
Tau protein interaction partners and their roles in Alzheimer's disease and other tauopathies
J Sinsky, K Pichlerova, J Hanes - International journal of molecular …, 2021 - mdpi.com
Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …
microtubules, which are important for the normal function of neurons and the brain. In …
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
Tauopathies are neurodegenerative diseases characterized by aberrant forms of tau protein
accumulation leading to neuronal death in focal brain areas. Positron emission tomography …
accumulation leading to neuronal death in focal brain areas. Positron emission tomography …
Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling
N Myeku, CL Clelland, S Emrani, NV Kukushkin… - Nature medicine, 2016 - nature.com
The ubiquitin proteasome system (UPS) degrades misfolded proteins including those
implicated in neurodegenerative diseases. We investigated the effects of tau accumulation …
implicated in neurodegenerative diseases. We investigated the effects of tau accumulation …
[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …