Key Points Sepsis and Septic Shock Sepsis is a syndrome of life-threatening acute organ
dysfunction due to bacterial, fungal, parasitic, or viral infection. Factors that affect the risk of …

Systematic reviews (SRs) are the highest standard of evidence, sha** clinical practice
guidelines, policy decisions, and research priorities. However, their labor-intensive nature …

A recent subgroup analysis of the APROCCHSS trial suggested that mortality benefits of
fludrocortisone–hydrocortisone versus placebo were heterogeneous; participants with …

Rationale: Uncertainty remains regarding the risks associated with single-dose use of
etomidate. Objectives: To assess the use of etomidate in critically ill patients and compare …

The classical function of the mineralocorticoid receptor (MR) is to maintain electrolytic
homeostasis and control extracellular volume and blood pressure. The MR is expressed in …

Objectives: Identify the mechanism of action of fludrocortisone. Evaluate the potential
adverse effects of fludrocortisone. Determine the need for appropriate monitoring strategies …

Introduction Sepsis is a common condition associated with significant morbidity and
mortality. Emergency physicians play a key role in the diagnosis and management of this …

Corticosteroids have been utilized in modern medicine for decades. Many indications have
been investigated across various treatment settings with both benefit and harm observed …

The use of systemic corticosteroids in sepsis is a key topic. Current guidelines suggest the
use of low dose of intravenous hydrocortisone for adults with vasopressordependent sepsis …

Aim This study aimed to evaluate the preclinical safety of Shenfu injection for the treatment
of sepsis. Tests were designed and conducted to determine the acute and long-term toxicity …