Sarcopenia is a systemic disease with progressive and generalized skeletal muscle
dysfunction defined by age-related low muscle mass, high content of muscle slow fibers, and …

Intron retention (IR) is an alternative splicing mode whereby introns, rather than being
spliced out as usual, are retained in mature mRNAs. It was previously considered a …

Alternative splicing (AS) is a major source of protein diversity in eukaryotes, but less is
known about its evolution compared to gene duplication (GD). How AS and GD interact is …

Background Gastrointestinal pan-adenocarcinomas, which mainly include
adenocarcinomas of the esophagus, stomach, colon, and rectum, place a heavy burden on …

Alternative splicing (AS) tremendously increases the use of genetic information by
generating protein isoforms that differ in protein–protein interactions, catalytic activity and/or …

Most human genes undergo alternative splicing (AS), and dysregulation of alternative
splicing contributes to tumor initiation and progression. Computational analysis of genomic …

Alternative splicing is an important step in eukaryotic mRNA pre-processing which increases
the complexity of gene expression programs, but is frequently altered in disease. Previous …

Introns can increase gene expression levels using a variety of mechanisms collectively
referred to as Intron Mediated Enhancement (IME). IME has been measured in cell culture …

The acquisition of somatic mutations is the most common event in cancer. Neoantigens
expressed from genes with mutations acquired during carcinogenesis can be tumor-specific …

Transcriptomic profiling has been applied to large numbers of cancer samples, by large-
scale consortia, including The Cancer Genome Atlas, International Cancer Genome …