Data continue to accumulate indicating that many systematic reviews are methodologically
flawed, biased, redundant, or uninformative. Some improvements have occurred in recent …

Background Cognitive bias modification (CBM) therapies, including attention bias
modification, interpretation bias modification, or approach and avoidance training, are …

Importance Personalized treatment choices would increase the effectiveness of internet-
based cognitive behavioral therapy (iCBT) for depression to the extent that patients differ in …

Subjective narrative review articles have an educational and informative role in medical and
scientific journals. Systematic review of the literature requires an objective and complete …

Importance Resuscitation with lower fractional inspired oxygen (FiO 2) reduces mortality in
term and near-term infants but the impact of this practice on very preterm infants is unclear …

Organisations such as the National Institute for Health and Care Excellence require the
synthesis of evidence from existing studies to inform their decisions—for example, about the …

Systematic reviews and pairwise meta-analyses of randomized controlled trials, at the
intersection of clinical medicine, epidemiology and statistics, are positioned at the top of …

Background Some studies have suggested a link between antihypertensive medication and
cancer, but the evidence is so far inconclusive. Thus, we aimed to investigate this …

Non‐randomized studies aim to reveal whether or not interventions are effective in real‐life
clinical practice, and there is a growing interest in including such evidence in the decision …

Introduction: High-quality randomised controlled trials (RCTs) provide the most reliable
evidence on the comparative efficacy of new medicines. However, non-randomised studies …