Potential health benefits of plant food-derived bioactive components: An overview

M Samtiya, RE Aluko, T Dhewa, JM Moreno-Rojas - Foods, 2021 - mdpi.com
Plant foods are consumed worldwide due to their immense energy density and nutritive
value. Their consumption has been following an increasing trend due to several metabolic …

[HTML][HTML] The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC)

R Farghadani, R Naidu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Breast cancer is a leadingcause of cancer-related deaths in women globally, with triple-
negative breast cancer (TNBC) being an aggressive subtype that lacks targeted therapies …

Promising bioactive properties of quercetin for potential food applications and health benefits: A review

I Shabir, V Kumar Pandey, R Shams, AH Dar… - Frontiers in …, 2022 - frontiersin.org
Naturally occurring phytochemicals with promising biological properties are quercetin and
its derivatives. Quercetin has been thoroughly studied for its antidiabetic, antibacterial, anti …

[HTML][HTML] Quercetin inhibits DNA damage responses to induce apoptosis via SIRT5/PI3K/AKT pathway in non-small cell lung cancer

B Zhou, Y Yang, X Pang, J Shi, T Jiang… - Biomedicine & …, 2023 - Elsevier
SIRT5 is a mitochondrial NAD+-dependent lysine deacylase. Downregulation of SIRT5 has
been linked to several primary cancers and DNA damage. In clinical therapy for non-small …

Endothelial dysfunction as a complication of anti-cancer therapy

JD Terwoord, AM Beyer, DD Gutterman - Pharmacology & therapeutics, 2022 - Elsevier
Recent strides in anti-cancer therapeutics have improved longevity and led to a growing
population of cancer survivors, who are increasingly likely to die of other causes. Treatment …

Natural bioactive compounds-doxorubicin combinations targeting topoisomerase II-alpha: Anticancer efficacy and safety

A Elfadadny, RF Ragab, R Hamada… - Toxicology and Applied …, 2023 - Elsevier
Cancer is one of the leading causes of death worldwide, so pursuing effective and safe
therapeutics for cancer is a key research objective nowadays. Doxorubicin (DOX) is one of …

Cytotoxic and chemomodulatory effects of Phyllanthus niruri in MCF-7 and MCF-7ADR breast cancer cells

OE Abdel-Sattar, RM Allam, AM Al-Abd, B Avula… - Scientific Reports, 2023 - nature.com
The members of the genus Phyllanthus have long been used in the treatment of a broad
spectrum of diseases. They exhibited antiproliferative activity against various human cancer …

Solid self-nano emulsifying nanoplatform loaded with tamoxifen and resveratrol for treatment of breast cancer

N Shrivastava, A Parikh, RP Dewangan, L Biswas… - Pharmaceutics, 2022 - mdpi.com
The solid self-nanoemulsifying drug delivery system (s-SNEDDS) is a growing platform for
the delivery of drugs via oral route. In the present work, tamoxifen (TAM) was loaded in …

Codelivery of Que and BCL-2 siRNA with lipid–copolymer hybrid nanocomplexes for efficient tumor regression

K Li, X Cai, Y Fan, M **, Y **e, Z **g… - ACS Biomaterials …, 2023 - ACS Publications
The efficacy of chemotherapy is often reduced due to the chemotherapy resistance of tumor
cells, which is usually caused by abnormal gene overexpression. Herein, multifunctional …

Luteolin prevents cardiac dysfunction and improves the chemotherapeutic efficacy of doxorubicin in breast cancer

Y Shi, F Li, M Shen, C Sun, W Hao, C Wu… - Frontiers in …, 2021 - frontiersin.org
Background: Doxorubicin (Dox) is one of the most effective chemotherapy agents used in
the treatment of solid tumors and hematological malignancies. However, it causes dose …