Modern quantitative image analysis techniques have enabled high-throughput, high-content
imaging experiments. Image-based profiling leverages the rich information in images to …

Measuring the phenotypic effect of treatments on cells through imaging assays is an efficient
and powerful way of studying cell biology, and requires computational methods for …

High-throughput image-based profiling platforms are powerful technologies capable of
collecting data from billions of cells exposed to thousands of perturbations in a time-and cost …

Morphological profiling is a valuable tool in phenotypic drug discovery. The advent of high-
throughput automated imaging has enabled the capturing of a wide range of morphological …

Image-based profiling has emerged as a powerful technology for various steps in basic
biological and pharmaceutical discovery, but the community has lacked a large, public …

Image-based or morphological profiling is a rapidly expanding field wherein cells are
'profiled'by extracting hundreds to thousands of unbiased, quantitative features from images …

The identification of genetic and chemical perturbations with similar impacts on cell
morphology can elucidate compounds' mechanisms of action or novel regulators of genetic …

The morphology of cells is dynamic and mediated by genetic and environmental factors.
Characterizing how genetic variation impacts cell morphology can provide an important link …

Cell Painting is an image-based assay that offers valuable insights into drug mechanisms of
action and off-target effects. However, traditional feature extraction tools such as CellProfiler …

Mitochondrial toxicity is a significant concern in the drug discovery process, as compounds
that disrupt the function of these organelles can lead to serious side effects, including liver …