[HTML][HTML] Physiology of cholangiocytes
JH Tabibian, AI Masyuk, TV Masyuk… - Comprehensive …, 2013 - ncbi.nlm.nih.gov
Cholangiocytes are epithelial cells that line the intra-and extrahepatic ducts of the biliary
tree. The main physiologic function of cholangiocytes is modification of hepatocyte-derived …
tree. The main physiologic function of cholangiocytes is modification of hepatocyte-derived …
Pathogenesis of cholestatic liver disease and therapeutic approaches
Cholestatic liver disorders are caused by genetic defects, mechanical aberrations, toxins, or
dysregulations in the immune system that damage the bile ducts and cause accumulation of …
dysregulations in the immune system that damage the bile ducts and cause accumulation of …
[HTML][HTML] Functional and structural features of cholangiocytes in health and disease
Cholangiocytes are the epithelial cells that line the bile ducts. Along the biliary tree, two
different kinds of cholangiocytes exist: small and large cholangiocytes. Each type has …
different kinds of cholangiocytes exist: small and large cholangiocytes. Each type has …
[PDF][PDF] The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor‐β1 biliary secretion in mice
The secretin/secretin receptor (SR) axis is up‐regulated by proliferating cholangiocytes
during cholestasis. Secretin stimulates biliary proliferation by down‐regulation of let‐7a and …
during cholestasis. Secretin stimulates biliary proliferation by down‐regulation of let‐7a and …
Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease
Introduction Nonalcoholic fatty liver disease (NAFLD) is one of the most important causes of
liver-related morbidity and mortality in children. Recently, we have reported the effects of …
liver-related morbidity and mortality in children. Recently, we have reported the effects of …
[HTML][HTML] Mechanisms of cholangiocyte responses to injury
Cholangiocytes, epithelial cells that line the biliary epithelium, are the primary target cells for
cholangiopathies including primary sclerosing cholangitis and primary biliary cholangitis …
cholangiopathies including primary sclerosing cholangitis and primary biliary cholangitis …
[HTML][HTML] The physiological roles of secretin and its receptor
S Afroze, F Meng, K Jensen, K McDaniel… - Annals of …, 2013 - ncbi.nlm.nih.gov
Secretin is secreted by S cells in the small intestine and affects the function of a number of
organ systems. Secretin receptors (SR) are expressed in the basolateral domain of several …
organ systems. Secretin receptors (SR) are expressed in the basolateral domain of several …
Stem/progenitor cell niches involved in hepatic and biliary regeneration
Niches containing stem/progenitor cells are present in different anatomical locations along
the human biliary tree and within liver acini. The most primitive stem/progenitors, biliary tree …
the human biliary tree and within liver acini. The most primitive stem/progenitors, biliary tree …
Inhibition of secretin/secretin receptor axis ameliorates NAFLD phenotypes
Background and Aims Human NAFLD is characterized at early stages by hepatic steatosis,
which may progress to NASH when the liver displays microvesicular steatosis, lobular …
which may progress to NASH when the liver displays microvesicular steatosis, lobular …
[HTML][HTML] Panic at the bile duct: how intrahepatic cholangiocytes respond to stress and injury
In the liver, biliary epithelial cells (BECs) line intrahepatic bile ducts (IHBDs) and are
primarily responsible for modifying and transporting hepatocyte-produced bile to the …
primarily responsible for modifying and transporting hepatocyte-produced bile to the …