The time and cost of develo** new drugs have led many groups to limit their search for
therapeutics to compounds that have previously been approved for human use. Many …

There is no description on the mechanisms associated with blood–brain barrier (BBB)
disruption during sepsis development. Thus, we here determined changes in permeability of …

Matrix metalloproteinases (MMPs) is a family of Zn 2+ endopeptidases that process various
components of the extracellular matrix. These enzymes are also involved in activation and …

Recent evidence suggests that matrix metalloproteinases (MMPs) and their endogenous
inhibitors are involved in the pathogenesis of sepsis. We studied serum levels of MMP-8 …

Matrix metalloproteinases (MMPs) are a family of proteases best known for their capacity to
proteolyse several proteins of the extracellular matrix. Their increased activity contributes to …

The structure and composition of the endothelial cell (EC) glycocalyx reflect a balance of the
biosynthesis of glycans and their shear dependent removal. Shedding of glycans from the …

One of the most frequent and serious complications to develop in septic patients is acute
kidney injury (AKI), a disorder characterized by a rapid failure of the kidneys to adequately …

Acute respiratory distress syndrome, a severe form of acute lung injury (ALI), is a major
cause of death during influenza pneumonia. We have provided evidence for the involvement …

The aim of this study is to determine the mechanism of sepsis‐induced vascular
hyperpermeability and the beneficial effect of glucocorticoid in protecting vascular …

This review outlines a literature‐based approach with illustrative examples of drug
repurposing (one molecule, multiple targets), which will be useful in tackling the problem of …