Intrinsically disordered proteins and their “mysterious”(meta) physics
VN Uversky - Frontiers in Physics, 2019 - frontiersin.org
Recognition of the natural abundance and functional importance of intrinsically disordered
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …
Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder
VN Uversky - Current opinion in structural biology, 2017 - Elsevier
Highlights•Eukaryotic cells are inhomogeneously crowded and contain various cellular
bodies.•Some of these bodies are proteinaceous membrane-less organelles …
bodies.•Some of these bodies are proteinaceous membrane-less organelles …
flDPnn: Accurate intrinsic disorder prediction with putative propensities of disorder functions
Identification of intrinsic disorder in proteins relies in large part on computational predictors,
which demands that their accuracy should be high. Since intrinsic disorder carries out a …
which demands that their accuracy should be high. Since intrinsic disorder carries out a …
IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding
The structural states of proteins include ordered globular domains as well as intrinsically
disordered protein regions that exist as highly flexible conformational ensembles in …
disordered protein regions that exist as highly flexible conformational ensembles in …
Improving protein disorder prediction by deep bidirectional long short-term memory recurrent neural networks
Motivation Capturing long-range interactions between structural but not sequence neighbors
of proteins is a long-standing challenging problem in bioinformatics. Recently, long short …
of proteins is a long-standing challenging problem in bioinformatics. Recently, long short …
MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins
The MobiDB (URL: mobidb. bio. unipd. it) database of protein disorder and mobility
annotations has been significantly updated and upgraded since its last major renewal in …
annotations has been significantly updated and upgraded since its last major renewal in …
Tutorial: a guide for the selection of fast and accurate computational tools for the prediction of intrinsic disorder in proteins
Intrinsic disorder is instrumental for a wide range of protein functions, and its analysis, using
computational predictions from primary structures, complements secondary and tertiary …
computational predictions from primary structures, complements secondary and tertiary …
Prediction of protein disorder based on IUPred
Z Dosztányi - Protein Science, 2018 - Wiley Online Library
Many proteins contain intrinsically disordered regions (IDRs), functional polypeptide
segments that in isolation adopt a highly flexible conformational ensemble instead of a …
segments that in isolation adopt a highly flexible conformational ensemble instead of a …
MobiDB-lite: fast and highly specific consensus prediction of intrinsic disorder in proteins
Motivation Intrinsic disorder (ID) is established as an important feature of protein sequences.
Its use in proteome annotation is however hampered by the availability of many methods …
Its use in proteome annotation is however hampered by the availability of many methods …
Comprehensive review of methods for prediction of intrinsic disorder and its molecular functions
Computational prediction of intrinsic disorder in protein sequences dates back to late 1970
and has flourished in the last two decades. We provide a brief historical overview, and we …
and has flourished in the last two decades. We provide a brief historical overview, and we …