In living cells, both newly made and preexisting polypeptide chains are at constant risk for
misfolding and aggregation. In accordance with the wide diversity of misfolded forms …

Helicases and translocases are a ubiquitous, highly diverse group of proteins that perform
an extraordinary variety of functions in cells. Consequently, this review sets out to define a …

Flaviviridae are small enveloped viruses hosting a positive-sense single-stranded RNA
genome. Besides yellow fever virus, a landmark case in the history of virology, members of …

Raman spectroscopy has become a versatile tool in protein science and biotechnology.
Recent advances in spectral assignments and vibrational theory, examples of use in …

An ATP-powered DNA translocation machine encapsidates the viral genome in the large
dsDNA bacteriophages. The essential components include the empty shell, prohead, and …

Is it possible to meaningfully comprehend the diversity of the viral world? We propose that it
is. This is based on the observation that, although there is immense genomic variation, every …

Homomeric ring ATPases perform many vital and varied tasks in the cell, ranging from
chromosome segregation to protein degradation. Here we report the direct observation of …

Translocation of viral double-stranded DNA (dsDNA) into the icosahedral prohead shell is
catalyzed by TerL, a motor protein that has ATPase, endonuclease, and translocase …

Hexameric helicases couple ATP hydrolysis to processive separation of nucleic acid
duplexes, a process critical for gene expression, DNA replication, and repair. All hexameric …

The bacterial phage shock protein (Psp) response functions to help cells manage the
impacts of agents impairing cell membrane function. The system has relevance to …