The neurotransmitters glutamate and γ-aminobutyric acid (GABA) transmit synaptic signals
by activating fast-acting ligand-gated ion channels and more slowly acting G-protein …

Oxidative stress has emerged as a key deleterious factor in brain ischemia and reperfusion.
Malfunction of the oxidative respiratory chain in mitochondria combines with the activation of …

When characterizing biomolecular interactions, avidity, is an umbrella term used to describe
the accumulated strength of multiple specific and unspecific interactions between two or …

Membrane-associated guanylate kinases (MAGUKs) are a family of scaffold proteins that are
highly enriched in synapses and are responsible for organizing the numerous protein …

N-methyl-d-aspartate receptors (NMDARs) are ligand-gated ion channels
('ionotropic'receptors) activated by the major excitatory neurotransmitter, l-glutamate. While …

Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

Therapies for stroke have remained elusive in the past despite the great relevance of this
pathology. However, recent results have provided strong evidence that postsynaptic density …

Targeting receptor proteins, such as ligand-gated ion channels and G protein-coupled
receptors, has directly enabled the discovery of most drugs developed to modulate receptor …