Actinide metal-organic frameworks (An-MOFs) consisting of actinide nodes and organic
linkers represent an underexplored category of coordination polymers due to challenges in …

This review outlines the accomplishments and potential developments of targeted alpha (α)
particle therapy (TAT). It discusses the therapeutic advantages of the short and highly …

Conspectus Current projections for global mining indicate that unsustainable practices will
cause supply problems for many elements, called critical raw materials, in the next 20 years …

Recent Food and Drug Administration (FDA) approval of diagnostic and therapeutic
radiopharmaceuticals and concurrent miniaturization of particle accelerators leading to …

Targeted alpha‐therapy (TAT) has great potential for treating a broad range of late‐stage
cancers by delivering a focused and lethal radiation dose to tumors. Actinium‐225 (225Ac) …

The widespread use of peptide receptor radionuclide therapy (PRRT) represents a major
therapeutic breakthrough in nuclear medicine, particularly since the introduction of 177Lu …

Targeted α-therapy (TAT) is an emerging powerful tool treating late-stage cancers for which
therapeutic options are limited. At the core of TAT are targeted radiopharmaceuticals, where …

Actinium-based therapies could revolutionize cancer medicine but remain tantalizing due to
the difficulties in studying and limited knowledge of Ac chemistry. Current efforts focus on …

To clinically advance the growing arsenal of radiometals available to image and treat
cancer, chelators with versatile binding properties are needed. Herein, we evaluated the …

Targeted alpha therapy (TAT) pairs the specificity of antigen targeting with the lethality of
alpha particles to eradicate cancerous cells. Actinium-225 [225Ac; t1/2= 9.920 (3) days] is an …