Overcoming roadblocks in the development of vaccines for leishmaniasis
PM Kaye, S Mohan, C Mantel, M Malhame… - Expert Review of …, 2021 - Taylor & Francis
Introduction The leishmaniases represent a group of parasitic diseases caused by infection
with one of several species of Leishmania parasites. Disease presentation varies because …
with one of several species of Leishmania parasites. Disease presentation varies because …
The delay in the licensing of protozoal vaccines: a comparative history
Although viruses and bacteria have been known as agents of diseases since 1546, 250
years went by until the first vaccines against these pathogens were developed (1796 and …
years went by until the first vaccines against these pathogens were developed (1796 and …
The impact of bioinformatics on vaccine design and development
RR María, CJ Arturo, JA Alicia, MG Paulina… - Vaccines, 2017 - books.google.com
Vaccines are the pharmaceutical products that offer the best cost‐benefit ratio in the pre‐-
vention or treatment of diseases. In that a vaccine is a pharmaceutical product, vaccine …
vention or treatment of diseases. In that a vaccine is a pharmaceutical product, vaccine …
Vaccinomics-based next-generation multi-epitope chimeric vaccine models prediction against Leishmania tropica - a hierarchical subtractive proteomics and …
Leishmania tropica is a vector-borne parasitic protozoa that is the leading cause of
leishmaniasis throughout the global tropics and subtropics. L. tropica is a multidrug-resistant …
leishmaniasis throughout the global tropics and subtropics. L. tropica is a multidrug-resistant …
Immunoinformatics Approach to Design a Multi-Epitope Nanovaccine against Leishmania Parasite: Elicitation of Cellular Immune Responses
Leishmaniasis is a vector-borne disease caused by an intracellular parasite of the genus
Leishmania with different clinical manifestations that affect millions of people worldwide …
Leishmania with different clinical manifestations that affect millions of people worldwide …
A Poly(Lactic-co-Glycolic) Acid Nanovaccine Based on Chimeric Peptides from Different Leishmania infantum Proteins Induces Dendritic Cells Maturation and Promotes …
Visceral leishmaniasis, caused by Leishmania (L.) donovani and L. infantum protozoan
parasites, can provoke overwhelming and protracted epidemics, with high case-fatality rates …
parasites, can provoke overwhelming and protracted epidemics, with high case-fatality rates …
Identification of Potential MHC Class-II-Restricted Epitopes Derived from Leishmania donovani Antigens by Reverse Vaccinology and Evaluation of Their CD4+ T …
Visceral leishmaniasis (VL) is one of the most neglected tropical diseases for which no
vaccine exists. In spite of extensive efforts, no successful vaccine is available against this …
vaccine exists. In spite of extensive efforts, no successful vaccine is available against this …
Vaccines for leishmaniasis and the implications of their development for American tegumentary leishmaniasis
B Coutinho De Oliveira, MS Duthie… - Human Vaccines & …, 2020 - Taylor & Francis
The leishmaniases are a collection of vector-borne parasitic diseases caused by a number
of different Leishmania species that are distributed worldwide. Clinical and laboratory …
of different Leishmania species that are distributed worldwide. Clinical and laboratory …
Identification of BALB/c Immune Markers Correlated with a Partial Protection to Leishmania infantum after Vaccination with a Rationally Designed Multi-epitope …
Background Through their increased potential to be engaged and processed by dendritic
cells (DCs), nanovaccines consisting of Poly (D, L-lactic-co-glycolic acid)(PLGA) …
cells (DCs), nanovaccines consisting of Poly (D, L-lactic-co-glycolic acid)(PLGA) …
A chimera containing CD4+ and CD8+ T-cell epitopes of the Leishmania donovani nucleoside hydrolase (NH36) optimizes cross-protection against Leishmania …
The Leishmania donovani nucleoside hydrolase (NH36) and NH A34480 of Leishmania
amazonensis share 93% of sequence identity. In mice, the NH36 induced protection against …
amazonensis share 93% of sequence identity. In mice, the NH36 induced protection against …