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Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
[HTML][HTML] MHC class I downregulation in cancer: underlying mechanisms and potential targets for cancer immunotherapy
AM Cornel, IL Mimpen, S Nierkens - Cancers, 2020 - mdpi.com
In recent years, major advances have been made in cancer immunotherapy. This has led to
significant improvement in prognosis of cancer patients, especially in the hematological …
significant improvement in prognosis of cancer patients, especially in the hematological …
Ubiquitination and deubiquitination in cancer: from mechanisms to novel therapeutic approaches
F Liu, J Chen, K Li, H Li, Y Zhu, Y Zhai, B Lu, Y Fan… - Molecular Cancer, 2024 - Springer
Ubiquitination, a pivotal posttranslational modification of proteins, plays a fundamental role
in regulating protein stability. The dysregulation of ubiquitinating and deubiquitinating …
in regulating protein stability. The dysregulation of ubiquitinating and deubiquitinating …
Immunotherapy for depression: Recent insights and future targets
Y Bai, Y Cai, D Chang, D Li, X Huo, T Zhu - Pharmacology & Therapeutics, 2024 - Elsevier
Depression stands as a prominent contributor to global disability, entailing an elevated risk
of suicide. Substantial evidence supports the notion that immune dysregulation may play a …
of suicide. Substantial evidence supports the notion that immune dysregulation may play a …
HECT E3 ligases: a tale with multiple facets
Ubiquitination plays a pivotal role in several cellular processes and is critical for protein
degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination …
degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination …
Autophagy in health and disease: From molecular mechanisms to therapeutic target
Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …
E3 ligases meet their match: fragment-based approaches to discover new E3 ligands and to unravel E3 biology
Ubiquitination is a key post-translational modification of proteins, affecting the regulation of
multiple cellular processes. Cells are equipped with over 600 ubiquitin orchestrators, called …
multiple cellular processes. Cells are equipped with over 600 ubiquitin orchestrators, called …
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes
HECT-family E3 ligases ubiquitinate protein substrates to control virtually every eukaryotic
process and are misregulated in numerous diseases. Nonetheless, understanding of HECT …
process and are misregulated in numerous diseases. Nonetheless, understanding of HECT …
The importance of regulatory ubiquitination in cancer and metastasis
Ubiquitination serves as a degradation mechanism of proteins, but is involved in additional
cellular processes such as activation of NFκB inflammatory response and DNA damage …
cellular processes such as activation of NFκB inflammatory response and DNA damage …
Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy
Asbestos causes malignant transformation of primary human mesothelial cells (HM), leading
to mesothelioma. The mechanisms of asbestos carcinogenesis remain enigmatic, as …
to mesothelioma. The mechanisms of asbestos carcinogenesis remain enigmatic, as …