[HTML][HTML] Identification of new rofecoxib-based cyclooxygenase-2 inhibitors: A bioinformatics approach

RP Leão, JV Cruz, GV da Costa, JN Cruz… - Pharmaceuticals, 2020 - mdpi.com
The cyclooxygenase-2 receptor is a therapeutic target for planning potential drugs with anti-
inflammatory activity. The selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib was …

Prodigiosin/PU-H71 as a novel potential combined therapy for triple negative breast cancer (TNBC): preclinical insights

MM Anwar, M Shalaby, AM Embaby, H Saeed… - Scientific Reports, 2020 - nature.com
Prodigiosin, a secondary metabolite red pigment produced by Serratia marcescens, has an
interesting apoptotic efficacy against cancer cell lines with low or no toxicity on normal cells …

Highly potent natural fungicides identified in silico against the cereal killer fungus Magnaporthe oryzae

MA Khan, MA Al Mamun Khan, A Mahfuz… - Scientific Reports, 2022 - nature.com
Magnaporthe oryzae is one of the most notorious fungal pathogens that causes blast
disease in cereals, and results in enormous loss of grain production. Many chemical …

In-silico prediction of highly promising natural fungicides against the destructive blast fungus Magnaporthe oryzae

MAAM Khan, A Ahsan, MA Khan, JM Sanjana… - Heliyon, 2023 - cell.com
Magnaporthe oryzae causes destructive blast disease in more than 50 species of the major
cereal crops rice, wheat and maize and destroys food of millions of people worldwide …

Larvicidal activity of coumarin derivatives on Toxocara canis larvae, cytotoxicity analysis, and in silico bioavailability studies

DC Rodrigues, CN de Oliveira da Cunha… - Parasitology …, 2024 - Springer
Human toxocariasis is a neglected anthropozoonosis with global distribution. Treatment is
based on the administration of anthelmintics; however, their effectiveness at the tissue level …

Evaluating chemotherapeutic potential of soya-isoflavonoids against high penetrance genes in triple-negative breast cancer

P Chatterjee, S Banerjee - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype of breast
cancer (BC) associated with a poor prognosis. Owing to the structural similarity with 17-β …

In silico molecular docking evaluation reveals high potencies of some natural antifungal metabolites on melanin biosynthesis and appressoria formation enzymes in …

MA Khan, MAAM Khan, JM Sanjana, A Ahsan… - 2022 - researchsquare.com
Magnaporthe oryzae is one of the most notorious fungal pathogens that causes blast
disease in cereals and results in enormous loss of grain production. Many chemical …

In Silico Screening of Triphala Churna against Bacterial Agents

LS Dhivya, M Haritha, GV Anjana… - Journal of Natural …, 2022 - informaticsjournals.co.in
Abstract Triphala Churna consisting Triphala and its constituents have been revealed to
have antibacterial properties against human pathogens. The phenolic ring of …

[PDF][PDF] Computational Analysis of Pharmacokinetic, Bioactivity and Toxicity Parameters of Some Selected Oral-hypoglycaemic Agents Shashank Shekhar Mishra …

S Sharma, HP Singh - 2018 - chemrj.org
Diabetes mellitus is a chronic, lifelong condition that affects body's ability to use the energy
found in food. The number of patients with DM is markedly increasing worldwide. Globally …

[PDF][PDF] In Silico Pharmacokinetic, Bioactivity and Toxicity Study of Some Selected Anti-Anginal Agents

SS Mishra, N Kumar, H Pandiya, HP Singh… - International Journal of … - scholar.archive.org
Angina pectoris is the major cardio-vascular disease that occurs due to the imbalance
between blood supply and demand that results obstruction of coronary arteries. WHO …