Laboratory diagnostic tools for syphilis: current status and future prospects

Y Luo, Y **e, Y **ao - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
With the increasing number of patients infected with syphilis in the past 20 years, early
diagnosis and early treatment are essential to decline syphilis prevalence. Owing to its …

Search and discovery strategies for biotechnology: the paradigm shift

AT Bull, AC Ward, M Goodfellow - Microbiology and Molecular …, 2000 - Am Soc Microbiol
Profound changes are occurring in the strategies that biotechnology-based industries are
deploying in the search for exploitable biology and to discover new products and develop …

The pathogenesis of syphilis: the Great Mimicker, revisited

RW Peeling, EW Hook III - The Journal of Pathology: A Journal …, 2006 - Wiley Online Library
Syphilis is a chronic sexually transmitted infection caused by Treponema pallidum
subspecies pallidum. Its protean clinical presentations earned it the name of the 'Great …

[PDF][PDF] Maternal syphilis: pathophysiology and treatment

SM Berman - Bulletin of the World Health Organization, 2004 - SciELO Public Health
Despite the long history of medical interest in syphilis and its effects on pregnancy outcome,
many fundamental questions about the pathophysiology and treatment of syphilis during …

Sodium ion cycle in bacterial pathogens: evidence from cross-genome comparisons

CC Häse, ND Fedorova, MY Galperin… - … and Molecular Biology …, 2001 - Am Soc Microbiol
Analysis of the bacterial genome sequences shows that many human and animal pathogens
encode primary membrane Na+ pumps, Na+-transporting dicarboxylate decarboxylases or …

[HTML][HTML] Ancient bacterial genomes reveal a high diversity of Treponema pallidum strains in early modern Europe

K Majander, S Pfrengle, A Kocher, J Neukamm… - Current Biology, 2020 - cell.com
Syphilis is a globally re-emerging disease, which has marked European history with a
devastating epidemic at the end of the 15 th century. Together with non-venereal treponemal …

Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains

VJ Schuenemann, A Kumar Lankapalli… - PLoS neglected …, 2018 - journals.plos.org
Treponema pallidum infections occur worldwide causing, among other diseases, syphilis
and yaws. In particular sexually transmitted syphilis is regarded as a re-emerging infectious …

[HTML][HTML] Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws

D Šmajs, SJ Norris, GM Weinstock - Infection, Genetics and Evolution, 2012 - Elsevier
Pathogenic uncultivable treponemes, similar to syphilis-causing Treponema pallidum
subspecies pallidum, include T. pallidum ssp. pertenue, T. pallidum ssp. endemicum and …

Opsonic Potential, Protective Capacity, and Sequence Conservation of the Treponema pallidum subspecies pallidum Tp92

CE Cameron, SA Lukehart, C Castro… - The Journal of …, 2000 - academic.oup.com
By means of a differential screening technique, a 92-kDa antigen, designated Tp92, was
identified from Treponema pallidum subspecies pallidum. This protein is similar in sequence …

PCR detection for syphilis diagnosis: Status and prospects

C Zhou, X Zhang, W Zhang, J Duan… - Journal of clinical …, 2019 - Wiley Online Library
Syphilis, a re‐emerging public health problem worldwide caused by Treponema pallidum
subsp pallidum (T. pallidum), usually induces systemic and chronic inflammation in hosts …