[HTML][HTML] Hyaluronic acid: a powerful biomolecule with wide-ranging applications—a comprehensive review

GN Iaconisi, P Lunetti, N Gallo, AR Cappello… - International journal of …, 2023 - mdpi.com
Hyaluronic acid (HA) is a glycosaminoglycan widely distributed in the human body,
especially in body fluids and the extracellular matrix of tissues. It plays a crucial role not only …

Shattering barriers toward clinically meaningful MSC therapies

O Levy, R Kuai, EMJ Siren, D Bhere, Y Milton… - Science …, 2020 - science.org
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

Mesenchymal stromal cell homing: mechanisms and strategies for improvement

M Ullah, DD Liu, AS Thakor - Iscience, 2019 - cell.com
Mesenchymal stromal cells (MSCs) have been widely investigated for their therapeutic
potential in regenerative medicine, owing to their ability to home damaged tissue and serve …

Manufacturing of primed mesenchymal stromal cells for therapy

JQ Yin, J Zhu, JA Ankrum - Nature biomedical engineering, 2019 - nature.com
Mesenchymal stromal cells (MSCs) for basic research and clinical applications are
manufactured and developed as unique cell products by many different manufacturers and …

Biomimetic cell-derived nanocarriers in cancer research

E Soprano, E Polo, B Pelaz, P Del Pino - Journal of Nanobiotechnology, 2022 - Springer
Nanoparticles have now long demonstrated capabilities that make them attractive to use in
biology and medicine. Some of them, such as lipid nanoparticles (SARS-CoV-2 vaccines) or …

Concise review: mesenchymal stem cell-based drug delivery: the good, the bad, the ugly, and the promise

TEG Krueger, DLJ Thorek… - Stem cells …, 2018 - academic.oup.com
The development of mesenchymal stem cells (MSCs) as cell-based drug delivery vectors for
numerous clinical indications, including cancer, has significant promise. However, a …

Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue

H Wang, CN Alarcón, B Liu, F Watson… - Nature biomedical …, 2022 - nature.com
Targeting the delivery of therapeutics specifically to diseased tissue enhances their efficacy
and decreases their side effects. Here we show that mesenchymal stromal cells with their …

Biomolecules-derived biomaterials

LP Datta, S Manchineella, T Govindaraju - Biomaterials, 2020 - Elsevier
Human civilization has witnessed the use of materials-derived from biomolecules of plants
and animal origin for biomedical applications since ancient era. In recent years, precision …

Mesenchymal stem cell exosomes as a cell-free therapy for nerve injury–induced pain in rats

SJ Shiue, RH Rau, HS Shiue, YW Hung, ZX Li… - Pain, 2019 - journals.lww.com
Nerve injury–induced neuropathic pain is difficult to treat. In this study, we used exosomes
derived from human umbilical cord mesenchymal stem cell (UCMSC) as a cell-free therapy …

Advancements in 3D cell culture systems for personalizing anti-cancer therapies

AMK Law, L Rodriguez de la Fuente, TJ Grundy… - Frontiers in …, 2021 - frontiersin.org
Over 90% of potential anti-cancer drug candidates results in translational failures in clinical
trials. The main reason for this failure can be attributed to the non-accurate pre-clinical …