Highlights•Available evidence suggests a positive link between PCSK9 levels and T2DM
incidence.•There is a scientific gap on the impact of PCSK9 inhibition on glycemic …

Highlights•Familial hypercholesterolemia (FH) is the most severe type of genetic
dyslipidemia.•There is evidence suggesting impaired HDL functionality in patients with …

Background Proprotein convertase subtilisin/kexin 9 (PCSK9) serves a key regulatory
function in the metabolism of low-density lipoprotein (LDL)-cholesterol (LDL-C) through …

Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as neural apoptosis
regulated convertase (NARC1), is a key modulator of cholesterol metabolism. PCSK9 …

A doença arterial coronariana desempenha um papel central no desenvolvimento de
cardiopatias isquêmicas, que incluem a angina e o infarto do miocárdio. Estas condições …

Monoclonal antibodies (mAbs) are important theranostic tools in the clinics due to their
affinity to bind with specific antigen. Since their development, mAbs have been impacted in …

Various clinical criteria have been developed to aid in the diagnosis of FH and are accepted
as an inexpensive, low technology, yet feasible, sensitive means of screening. Multiple …

Despite the progress made during the past decade in the diagnosis and treatment of
cardiovascular diseases, a substantial number of patients continue to suffer from acute …

PCSK9 是一种属于枯草杆菌蛋白酶亚族, 由肝脏合成并负责调控蛋白质活性的丝氨酸蛋白酶.
有研究发现, 鼠科动物实验中PCSK9 过表达能引起LDL-R (低密度脂蛋白受体) 减少, LDL-C …

The clinical adverse reaction monitoring data of Human subtilisin converting enzyme 9 gene
(proprotein converting enzyme subtilisin/kexin type 9, PCSK9) inhibitors showed that there …