Schizophrenia genomics: genetic complexity and functional insights
Determining the causes of schizophrenia has been a notoriously intractable problem,
resistant to a multitude of investigative approaches over centuries. In recent decades …
resistant to a multitude of investigative approaches over centuries. In recent decades …
Innate immunity system in patients with cardiovascular and kidney disease
With a global burden of 844 million, chronic kidney disease (CKD) is now considered a
public health priority. Cardiovascular risk is pervasive in this population, and low-grade …
public health priority. Cardiovascular risk is pervasive in this population, and low-grade …
Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study
Background Sepsis is characterised by dysregulated, life-threatening immune responses,
which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in …
which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in …
Pleiotropic genetic architecture and novel loci for C-reactive protein levels
C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic
loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes …
loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes …
Inflammatory biomarkers and risk of Psychiatric disorders
Y Zeng, C Chourpiliadis, N Hammar, C Seitz… - JAMA …, 2024 - jamanetwork.com
Importance Individuals with psychiatric disorders have been reported to have elevated
levels of inflammatory biomarkers, and prospective evidence is limited regarding the …
levels of inflammatory biomarkers, and prospective evidence is limited regarding the …
C-reactive protein: pathophysiology, diagnosis, false test results and a novel diagnostic algorithm for clinicians
DS Mouliou - Diseases, 2023 - mdpi.com
The current literature provides a body of evidence on C-Reactive Protein (CRP) and its
potential role in inflammation. However, most pieces of evidence are sparse and …
potential role in inflammation. However, most pieces of evidence are sparse and …
Examining the shared etiology of psychopathology with genome-wide association studies
Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
Investigating causal relationships between obesity and skin barrier function in a multi-ethnic Asian general population cohort
Background Skin diseases impact significantly on the quality of life and psychology of
patients. Obesity has been observed as a risk factor for skin diseases. Skin epidermal barrier …
patients. Obesity has been observed as a risk factor for skin diseases. Skin epidermal barrier …
Low levels of small HDL particles predict but do not influence risk of sepsis
Background Low levels of high-density lipoprotein (HDL) cholesterol have been associated
with higher rates and severity of infection. Alterations in inflammatory mediators and …
with higher rates and severity of infection. Alterations in inflammatory mediators and …
Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease
Major depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid,
resulting in excess morbidity and mortality. Here we show that CVDs share most of their …
resulting in excess morbidity and mortality. Here we show that CVDs share most of their …