Mechanisms of interplay between transcription factors and the 3D genome

S Kim, J Shendure - Molecular cell, 2019 - cell.com
Transcription factors (TFs) bind DNA in a sequence-specific manner and thereby serve as
the protein anchors and determinants of 3D genome organization. Conversely, chromatin …

Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions

M Raices, MA D'angelo - Nature reviews Molecular cell biology, 2012 - nature.com
Nuclear pore complexes (NPCs) are multiprotein aqueous channels that penetrate the
nuclear envelope connecting the nucleus and the cytoplasm. NPCs consist of multiple …

Dynamic pigmentary and structural coloration within cephalopod chromatophore organs

TL Williams, SL Senft, J Yeo, FJ Martín-Martínez… - Nature …, 2019 - nature.com
Chromatophore organs in cephalopod skin are known to produce ultra-fast changes in
appearance for camouflage and communication. Light-scattering pigment granules within …

Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation

T Roychowdhury, SW McNutt, C Pasala… - Nature …, 2024 - nature.com
The intricate network of protein-chaperone interactions is crucial for maintaining cellular
function. Recent discoveries have unveiled the existence of specialized chaperone …

Chromatin organization and transcriptional regulation

MR Hübner, MA Eckersley-Maslin… - Current opinion in genetics …, 2013 - Elsevier
Cell type specific transcriptional regulation must be adhered to in order to maintain cell
identity throughout the lifetime of an organism, yet it must be flexible enough to allow for …

Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory

A D'Urso, Y Takahashi, B **ong, J Marone, R Coukos… - Elife, 2016 - elifesciences.org
In yeast and humans, previous experiences can lead to epigenetic transcriptional memory:
repressed genes that exhibit mitotically heritable changes in chromatin structure and …

Nuclear pore proteins and the control of genome functions

A Ibarra, MW Hetzer - Genes & development, 2015 - genesdev.cshlp.org
Nuclear pore complexes (NPCs) are composed of several copies of∼ 30 different proteins
called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the …

Nuclear pore complexes and regulation of gene expression

M Raices, MA D'Angelo - Current opinion in cell biology, 2017 - Elsevier
Highlights•Nuclear pore complexes and nucleoporins have many transport-independent
functions.•Nuclear pore complexes play key roles in gene expression regulation.•In yeast …

Lamin A/C-promoter interactions specify chromatin state–dependent transcription outcomes

E Lund, AR Oldenburg, E Delbarre, CT Freberg… - Genome …, 2013 - genome.cshlp.org
The nuclear lamina is implicated in the organization of the eukaryotic nucleus. Association of
nuclear lamins with the genome occurs through large chromatin domains including mostly …

A R-loop sensing pathway mediates the relocation of transcribed genes to nuclear pore complexes

A Penzo, M Dubarry, C Brocas, M Zheng… - Nature …, 2023 - nature.com
Nuclear pore complexes (NPCs) have increasingly recognized interactions with the
genome, as exemplified in yeast, where they bind transcribed or damaged chromatin. By …