Basement membranes are widely distributed extracellular matrices that coat the basal
aspect of epithelial and endothelial cells and surround muscle, fat, and Schwann cells …

Myelinated nerve fibers are essential for the rapid propagation of action potentials by
saltatory conduction. They form as the result of reciprocal interactions between axons and …

Regeneration refers to regrowth of tissue in the central nervous system. It includes
generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential …

In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

Peripheral nerves contain large myelinated and small unmyelinated (Remak) fibers that
perform different functions. The choice to myelinate or not is dictated to Schwann cells by the …

Glial cells and neurons are engaged in a continuous and highly regulated bidirectional
dialog. A remarkable example is the control of myelination. Oligodendrocytes in the central …

Glial cells in the peripheral nervous system (PNS), which arise from the neural crest, include
axon-associated Schwann cells (SCs) in nerves, synapse-associated SCs at the …

Dynamic interactions of cells with their environment regulate multiple aspects of tissue
morphogenesis and function. Integrins are the major class of cell surface receptors that …

Schwann cells in the peripheral nervous system (PNS) are essential for the support and
myelination of axons, ensuring fast and accurate communication between the central …

Peripheral nerve injuries are common conditions that can arise from trauma (eg,
compression, severance) and can lead to neuropathic pain as well as motor and sensory …