Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Inflammation, Aging, and Cardiovascular Disease: JACC Review Topic of the Week
Aging and inflammation both contribute pivotally to cardiovascular (CV) and cerebrovascular
disease, the leading causes of death and disability worldwide. The concept of inflamm-aging …
disease, the leading causes of death and disability worldwide. The concept of inflamm-aging …
Accelerated biological aging in COVID-19 patients
Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous
findings indicate that epigenetic age could be altered in viral infection. However, the …
findings indicate that epigenetic age could be altered in viral infection. However, the …
Sex differences in biological aging with a focus on human studies
S Hägg, J Jylhävä - Elife, 2021 - elifesciences.org
Aging is a complex biological process characterized by hallmark features accumulating over
the life course, sha** the individual's aging trajectory and subsequent disease risks. There …
the life course, sha** the individual's aging trajectory and subsequent disease risks. There …
Telomere length as a marker of biological age: state-of-the-art, open issues, and future perspectives
A Vaiserman, D Krasnienkov - Frontiers in genetics, 2021 - frontiersin.org
Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …
aging. An accelerated rate of telomere attrition is also a common feature of age-related …
DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
Epigenetic clock: A promising biomarker and practical tool in aging
R Duan, Q Fu, Y Sun, Q Li - Ageing Research Reviews, 2022 - Elsevier
As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …
Measuring biological aging in humans: A quest
The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …
Advances in epigenetics link genetics to the environment and disease
Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …
excitement and hope, but also a degree of hype. Here we review how the field has evolved …
GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality
The aging process is characterized by the presence of high interindividual variation between
individuals of the same chronical age prompting a search for biomarkers that capture this …
individuals of the same chronical age prompting a search for biomarkers that capture this …