The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

The Japanese Society of Hypertension (JSH) revised the Guidelines for the Management of
Hypertension 2014 (JSH 2014), and published the JSH 2019. In the development of the JSH …

Abstract The “metabolic syndrome”(MetS) is a clustering of components that reflect
overnutrition, sedentary lifestyles, and resultant excess adiposity. The MetS includes the …

The prevalence of obesity-related glomerulopathy is increasing in parallel with the
worldwide obesity epidemic. Glomerular hypertrophy and adaptive focal segmental …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in more
than 5% of hepatocytes in the absence of excessive alcohol consumption and other …

Background. Chronic kidney disease (CKD) is a growing health problem worldwide that
leads to end-stage kidney failure and cardiovascular complications. We aimed to determine …

Results Eleven studies (n= 30,146) were included. MetS was significantly associated with
the development of eGFR< 60 ml/min per 1.73 m 2 (odds ratio, 1.55; 95% CI, 1.34, 1.80) …

The global increase in chronic kidney disease (CKD) parallels the obesity epidemic. Obesity
conveys a gradual but independent risk of progression of CKD that seems irrespective of the …

There is an epidemic of obesity and the metabolic syndrome in the United States and across
the world. Both entities are associated with high mortality, mainly as a result of …