PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …

Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine
kinase family. PLK1 has a key role in the progression of mitosis and recent evidence …

Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …

Genome instability has been identified as one of the enabling hallmarks in cancer. DNA
damage response (DDR) network is responsible for maintenance of genome integrity in …

Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …

Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression,
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …

The repair of DNA lesions that occur endogenously or in response to diverse genotoxic
stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways …

Maturation-promoting factor, an activity that can mediate mitotic entry, was discovered in
1971, and during the late 80s was characterized as a complex of cyclin B and Cdk1. Soon …

Commitment to mitosis must be tightly coordinated with DNA replication to preserve genome
integrity. While we have previously established that the timely activation of CyclinB1-Cdk1 in …

The hypoxia-inducible factor α-subunits (HIFα) are key transcription factors in the
mammalian response to oxygen deficiency. The HIFα regulation in response to hypoxia …