The role of adult hippocampal neurogenesis in brain health and disease

T Toda, SL Parylak, SB Linker, FH Gage - Molecular psychiatry, 2019 - nature.com
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity

F Calabrese, AC Rossetti, G Racagni… - Frontiers in cellular …, 2014 - frontiersin.org
Cytokines are key regulatory mediators involved in the host response to immunological
challenges, but also play a critical role in the communication between the immune and the …

[HTML][HTML] Dynamics of hippocampal neurogenesis in adult humans

KL Spalding, O Bergmann, K Alkass, S Bernard… - Cell, 2013 - cell.com
Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is
evidence for hippocampal neurogenesis in adult humans, although whether its extent is …

The neurobiology of depression and antidepressant action

P Willner, J Scheel-Krüger, C Belzung - Neuroscience & biobehavioral …, 2013 - Elsevier
We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Adult neuroplasticity: more than 40 years of research

E Fuchs, G Flügge - Neural plasticity, 2014 - Wiley Online Library
Within the last four decades, our view of the mature vertebrate brain has changed
significantly. Today it is generally accepted that the adult brain is far from being fixed. A …

Recalibrating the relevance of adult neurogenesis

JS Snyder - Trends in neurosciences, 2019 - cell.com
Conflicting reports about whether adult hippocampal neurogenesis occurs in humans raise
questions about its significance for human health and the relevance of animal models …

Neurogenesis, inflammation and behavior

RA Kohman, JS Rhodes - Brain, behavior, and immunity, 2013 - Elsevier
Before the 1990s it was widely believed that the adult brain was incapable of regenerating
neurons. However, it is now established that new neurons are continuously produced in the …

Environment and brain plasticity: towards an endogenous pharmacotherapy

A Sale, N Berardi, L Maffei - Physiological reviews, 2014 - journals.physiology.org
Brain plasticity refers to the remarkable property of cerebral neurons to change their
structure and function in response to experience, a fundamental theoretical theme in the …

A multiomic atlas of the aging hippocampus reveals molecular changes in response to environmental enrichment

RF Pérez, P Tezanos, A Peñarroya… - Nature …, 2024 - nature.com
Aging involves the deterioration of organismal function, leading to the emergence of multiple
pathologies. Environmental stimuli, including lifestyle, can influence the trajectory of this …

Adult hippocampal neurogenesis: regulation and possible functional and clinical correlates

P Baptista, JP Andrade - Frontiers in neuroanatomy, 2018 - frontiersin.org
The formation of new neurons in the adult central nervous system (CNS) has been
recognized as one of the major findings in neuroanatomical research. The hippocampal …