Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea
We present two standards developed by the Genomic Standards Consortium (GSC) for
reporting bacterial and archaeal genome sequences. Both are extensions of the Minimum …
reporting bacterial and archaeal genome sequences. Both are extensions of the Minimum …
Fungal secondary metabolism: regulation, function and drug discovery
NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
K Blin, S Shaw, K Steinke, R Villebro… - Nucleic acids …, 2019 - academic.oup.com
Secondary metabolites produced by bacteria and fungi are an important source of
antimicrobials and other bioactive compounds. In recent years, genome mining has seen …
antimicrobials and other bioactive compounds. In recent years, genome mining has seen …
MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters
With an ever-increasing amount of (meta) genomic data being deposited in sequence
databases,(meta) genome mining for natural product biosynthetic pathways occupies a …
databases,(meta) genome mining for natural product biosynthetic pathways occupies a …
MIBiG 2.0: a repository for biosynthetic gene clusters of known function
Fueled by the explosion of (meta) genomic data, genome mining of specialized metabolites
has become a major technology for drug discovery and studying microbiome ecology. In …
has become a major technology for drug discovery and studying microbiome ecology. In …
antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification
Many antibiotics, chemotherapeutics, crop protection agents and food preservatives
originate from molecules produced by bacteria, fungi or plants. In recent years, genome …
originate from molecules produced by bacteria, fungi or plants. In recent years, genome …
Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome
Microorganisms living inside plants can promote plant growth and health, but their genomic
and functional diversity remain largely elusive. Here, metagenomics and network inference …
and functional diversity remain largely elusive. Here, metagenomics and network inference …
Streptomyces: The biofactory of secondary metabolites
Natural products derived from microorganisms serve as a vital resource of valuable
pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial …
pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial …
BAGEL4: a user-friendly web server to thoroughly mine RiPPs and bacteriocins
Interest in secondary metabolites such as RiPPs (ribosomally synthesized and
posttranslationally modified peptides) is increasing worldwide. To facilitate the research in …
posttranslationally modified peptides) is increasing worldwide. To facilitate the research in …
A computational framework to explore large-scale biosynthetic diversity
Genome mining has become a key technology to exploit natural product diversity. Although
initially performed on a single-genome basis, the process is now being scaled up to mine …
initially performed on a single-genome basis, the process is now being scaled up to mine …