Natural products derived from microorganisms serve as a vital resource of valuable
pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial …

One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

With an ever-increasing amount of (meta) genomic data being deposited in sequence
databases,(meta) genome mining for natural product biosynthetic pathways occupies a …

Secondary metabolites produced by bacteria and fungi are an important source of
antimicrobials and other bioactive compounds. In recent years, genome mining has seen …

Fueled by the explosion of (meta) genomic data, genome mining of specialized metabolites
has become a major technology for drug discovery and studying microbiome ecology. In …

Novel antibiotics are urgently needed to address the looming global crisis of antibiotic
resistance. Historically, the primary source of clinically used antibiotics has been microbial …

Microorganisms living inside plants can promote plant growth and health, but their genomic
and functional diversity remain largely elusive. Here, metagenomics and network inference …

To support an ever-increasing population, modern agriculture faces numerous challenges
that pose major threats to global food and energy security. Plant-associated microbes, with …

All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

Genome mining has become a key technology to exploit natural product diversity. Although
initially performed on a single-genome basis, the process is now being scaled up to mine …