Self-renewal in the intestinal epithelia is fueled by a population of undifferentiated intestinal
stem cells (ISCs) that give rise to daughter or progenitor cells, which can subsequently …

The range of radiation threats we face today includes everything from individual radiation
exposures to mass casualties resulting from a terrorist incident, and many of these exposure …

We describe a method for treating germ-free (GF) mice with γ-irradiation and transplanting
them with normal or genetically manipulated bone marrow while maintaining their GF status …

Ionizing radiation (IR) induces p53-dependent apoptosis in radiosensitive tissues,
suggesting that p53 is a determinant of radiation syndromes. In fact, p53-deficient mice …

The mammalian gastrointestinal tract harbors a highly complex microbial community that
comprises hundreds of different types of bacterial cells. The gastrointestinal microbiota plays …

High-dose ionizing radiation induces severe DNA damage in the epithelial stem cells in
small intestinal crypts and causes gastrointestinal syndrome (GIS). Although the tumour …

New gastrointestinal symptoms are frequent after pelvic radiotherapy and can greatly affect
the quality of life of cancer survivors. The effect of radiation on the intestinal microbiota, and …

Vanin-1 is an epithelial ectoenzyme with pantetheinase activity and generating the amino-
thiol cysteamine through the metabolism of pantothenic acid (vitamin B 5). Here we show …

Radiotherapy is one of the most relevant treatment options for cancer therapy with or without
other treatment modalities including immunotherapy, surgery and chemotherapy. Exposure …

The goals of this study were to evaluate the effects of ionizing radiation on apical junctions in
colonic epithelium and mucosal barrier function in mice in vivo. Adult mice were subjected to …