ERK signalling: a master regulator of cell behaviour, life and fate
H Lavoie, J Gagnon, M Therrien - Nature reviews Molecular cell biology, 2020 - nature.com
The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
J Yuan, X Dong, J Yap, J Hu - Journal of hematology & oncology, 2020 - Springer
Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by
relaying extracellular signals to intracellular responses. In mammals, there are more than a …
relaying extracellular signals to intracellular responses. In mammals, there are more than a …
Protective autophagy elicited by RAF→ MEK→ ERK inhibition suggests a treatment strategy for RAS-driven cancers
Pancreatic ductal adenocarcinoma (PDA) was responsible for~ 44,000 deaths in the United
States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically …
States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically …
Deconvoluting the context-dependent role for autophagy in cancer
E White - Nature reviews cancer, 2012 - nature.com
Autophagy (also known as macroautophagy) captures intracellular components in
autophagosomes and delivers them to lysosomes, where they are degraded and recycled …
autophagosomes and delivers them to lysosomes, where they are degraded and recycled …
AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function
DG Hardie - Genes & development, 2011 - genesdev.cshlp.org
AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
G Bollag, P Hirth, J Tsai, J Zhang, PN Ibrahim, H Cho… - Nature, 2010 - nature.com
B-RAF is the most frequently mutated protein kinase in human cancers. The finding that
oncogenic mutations in BRAF are common in melanoma, followed by the demonstration that …
oncogenic mutations in BRAF are common in melanoma, followed by the demonstration that …
The LKB1–AMPK pathway: metabolism and growth control in tumour suppression
DB Shackelford, RJ Shaw - Nature Reviews Cancer, 2009 - nature.com
In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …
RAF-MEK-ERK pathway in cancer evolution and treatment
Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
[HTML][HTML] AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo
AMPK is a metabolic sensor that helps maintain cellular energy homeostasis. Despite
evidence linking AMPK with tumor suppressor functions, the role of AMPK in tumorigenesis …
evidence linking AMPK with tumor suppressor functions, the role of AMPK in tumorigenesis …