The conne**on between sex and immune responses

KS Forsyth, N Jiwrajka, CD Lovell… - Nature Reviews …, 2024‏ - nature.com
There are notable sex-based differences in immune responses to pathogens and self-
antigens, with female individuals exhibiting increased susceptibility to various autoimmune …

Sex differences in immunity

NM Wilkinson, HC Chen, MG Lechner… - Annual review of …, 2022‏ - annualreviews.org
Strong epidemiological evidence now exists that sex is an important biologic variable in
immunity. Recent studies, for example, have revealed that sex differences are associated …

Insights and implications of sexual dimorphism in osteoporosis

YY Zhang, N **e, XD Sun, EC Nice, YC Liou, C Huang… - Bone research, 2024‏ - nature.com
Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

Sex bias in lymphocytes: Implications for autoimmune diseases

KC Dodd, M Menon - Frontiers in Immunology, 2022‏ - frontiersin.org
Autoimmune diseases are characterized by a significant sex dimorphism, with women
showing increased susceptibility to disease. This is, at least in part, due to sex-dependent …

Sex hormones affect the pathogenesis and clinical characteristics of systemic lupus erythematosus

JW Kim, HA Kim, CH Suh, JY Jung - Frontiers in medicine, 2022‏ - frontiersin.org
Systemic lupus erythematosus (SLE) affects women more frequently than men, similar to the
female predilection for other autoimmune diseases. Moreover, male patients with SLE …

Sex steroids and autoimmune rheumatic diseases: state of the art

M Cutolo, RH Straub - Nature Reviews Rheumatology, 2020‏ - nature.com
In autoimmune rheumatic diseases, oestrogens can stimulate certain immune responses
(including effects on B cells and innate immunity), but can also have dose-related anti …

Revisiting steroidogenesis and its role in immune regulation with the advanced tools and technologies

S Chakraborty, J Pramanik, B Mahata - Genes & Immunity, 2021‏ - nature.com
Historically tools and technologies facilitated scientific discoveries. Steroid hormone
research is not an exception. Unfortunately, the dramatic advancement of the field faded this …

Contemporary incidence and prevalence of rheumatic fever and rheumatic heart disease in Australia using linked data: the case for policy change

JM Katzenellenbogen, D Bond‐Smith… - Journal of the …, 2020‏ - ahajournals.org
Background In 2018, the World Health Organization prioritized control of acute rheumatic
fever (ARF) and rheumatic heart disease (RHD), including disease surveillance. We …

Influence of androgens on immunity to self and foreign: effects on immunity and cancer

I Ben-Batalla, ME Vargas-Delgado… - Frontiers in …, 2020‏ - frontiersin.org
It is well-known that sex hormones can directly and indirectly influence immune cell function.
Different studies support a suppressive role of androgens on different components of the …

Immune cells, gut microbiota, and vaccines: a gender perspective

P Rio, M Caldarelli, M Chiantore, F Ocarino, M Candelli… - Cells, 2024‏ - mdpi.com
The development of preventive and therapeutic vaccines has played a crucial role in
preventing infections and treating chronic and non-communicable diseases, respectively …