Overcoming barriers to patient adherence: the case for develo** innovative drug delivery systems

TH Baryakova, BH Pogostin, R Langer… - Nature Reviews Drug …, 2023‏ - nature.com
Poor medication adherence is a pervasive issue with considerable health and
socioeconomic consequences. Although the underlying reasons are generally understood …

[HTML][HTML] Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

S Lyu, Z Dong, X Xu, HP Bei, HY Yuen, CWJ Cheung… - Bioactive materials, 2023‏ - Elsevier
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its
non-invasiveness, painless and simple administration, controllable drug delivery, and …

[HTML][HTML] Dissolving microneedles: Applications and growing therapeutic potential

Z Sartawi, C Blackshields, W Faisal - Journal of Controlled Release, 2022‏ - Elsevier
Microneedles are a rapidly develo** method for the transdermal delivery of therapeutic
compounds. All types of microneedles, whether solid, hollow, coated, or dissolving function …

Microneedle-based biosensing

LK Vora, AH Sabri, PE McKenna, A Himawan… - Nature Reviews …, 2024‏ - nature.com
Microneedles (MNs) are microscopic needles that are applied to the skin in a minimally
invasive way to facilitate transdermal drug delivery and/or uptake of interstitial fluid from the …

Microneedle for transdermal drug delivery: current trends and fabrication

JH Jung, SG ** - Journal of pharmaceutical investigation, 2021‏ - Springer
Background Transdermal delivery has the advantage of bypassing the first-pass effect and
allowing sustained release of the drug. However, the drug delivery is limited owing to the …

The role of 3D printing technology in microengineering of microneedles

U Detamornrat, E McAlister, ARJ Hutton, E Larrañeta… - Small, 2022‏ - Wiley Online Library
Microneedles (MNs) are minimally invasive devices, which have gained extensive interest
over the past decades in various fields including drug delivery, disease diagnosis …

Sampling dermal interstitial fluid using microneedles: a review of recent developments in sampling methods and microneedle‐based biosensors

KM Saifullah, Z Faraji Rad - Advanced Materials Interfaces, 2023‏ - Wiley Online Library
Although interstitial fluid (ISF) is recognized as an important source of biomarkers, it is
difficult and time‐consuming to extract, thus limiting its use in medical diagnostic and clinical …

Design principles of microneedles for drug delivery and sampling applications

Z Le, J Yu, YJ Quek, B Bai, X Li, Y Shou, B Myint, C Xu… - Materials Today, 2023‏ - Elsevier
Microneedles technology is a powerful platform to achieve efficient transdermal delivery of
bioactive molecules for local or systemic therapies attributing to their minimally invasive …

[HTML][HTML] Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development

E Larrañeta, REM Lutton, AD Woolfson… - Materials Science and …, 2016‏ - Elsevier
Transdermal drug delivery offers a number of advantages for the patient, due not only its non-
invasive and convenient nature, but also factors such as avoidance of first pass metabolism …

A review of recent advances in microneedle technology for transdermal drug delivery

R Nagarkar, M Singh, HX Nguyen… - Journal of Drug Delivery …, 2020‏ - Elsevier
Transdermal devices are used to deliver drugs through the skin. However, limitations such
as molecular weight and hydrophilicity of the molecules prevent its wider use. Microneedle …