Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …

The assignment of functions to uncharacterized proteins discovered in genome projects
requires easily accessible tools and computational resources for large-scale, user-friendly …

Biocatalysts are the backbone of bioprocessing industries that are going through a phase of
transition with reference to the requirement of extraordinary enzymes for various …

Abstract The Enzyme Function Initiative (EFI) provides a web resource with “genomic
enzymology” web tools to leverage the protein (UniProt) and genome (European Nucleotide …

Biaryl compounds, with two connected aromatic rings, are found across medicine, materials
science and asymmetric catalysis,. The necessity of joining arene building blocks to access …

The radical SAM superfamily (RSS), arguably the most functionally diverse enzyme
superfamily, is also one of the largest with∼ 700 K members currently in the UniProt …

Archaea synthesize isoprenoid-based ether-linked membrane lipids, which enable them to
withstand extreme environmental conditions, such as high temperatures, high salinity, and …

Carbapenems are antibiotics of last resort in the clinic. Owing to their potency and broad-
spectrum activity, they are an important part of the antibiotic arsenal. The vital role of …

Cyclic peptide natural products have served as important drug molecules, with several
examples used clinically. Enzymatic or chemical macrocyclization is the key transformation …

Rieske nonheme iron oxygenases use two metallocenters, a Rieske-type [2Fe-2S] cluster
and a mononuclear iron center, to catalyze oxidation reactions on a broad range of …