The myth of optimality in clinical neuroscience

AJ Holmes, LM Patrick - Trends in cognitive sciences, 2018 - cell.com
Clear evidence supports a dimensional view of psychiatric illness. Within this framework the
expression of disorder-relevant phenotypes is often interpreted as a breakdown or departure …

Human variation in pelvic shape and the effects of climate and past population history

L Betti - The Anatomical Record, 2017 - Wiley Online Library
The human pelvis is often described as an evolutionary compromise (obstetrical dilemma)
between the requirements of efficient bipedal locomotion and safe parturition of a highly …

Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk

TD Capellini, H Chen, J Cao, AC Doxey, AM Kiapour… - Nature …, 2017 - nature.com
Variants in GDF5 are associated with human arthritis and decreased height, but the causal
mutations are still unknown. We surveyed the Gdf5 locus for regulatory regions in transgenic …

Inferring human neutral genetic variation from craniodental phenotypes

H Rathmann, S Perretti, V Porcu, T Hanihara… - PNAS …, 2023 - academic.oup.com
There is a growing consensus that global patterns of modern human cranial and dental
variation are shaped largely by neutral evolutionary processes, suggesting that craniodental …

Constraint, natural selection, and the evolution of human body form

KRR Savell, BM Auerbach… - Proceedings of the …, 2016 - National Acad Sciences
Variation in body form among human groups is structured by a blend of natural selection
driven by local climatic conditions and random genetic drift. However, attempts to test …

Get a grip: Variation in human hand grip strength and implications for human evolution

A Bardo, TL Kivell, K Town, G Donati, H Ballieux… - Symmetry, 2021 - mdpi.com
Although hand grip strength is critical to the daily lives of humans and our arboreal great ape
relatives, the human hand has changed in form and function throughout our evolution due to …

Population history and ecology, in addition to climate, influence human stature and body proportions

E Pomeroy, JT Stock, JCK Wells - Scientific Reports, 2021 - nature.com
Worldwide variation in human stature and limb proportions is widely accepted to reflect
thermal adaptation, but the contribution of population history to this variation is unknown …

Human cold adaptation: An unfinished agenda v2. 0

C Ocobock - American Journal of Human Biology, 2024 - Wiley Online Library
Background Research on human extreme cold climate adaptations has benefitted from a
recent resurgence since Ted Steegmann laid out his Human Cold Adaptation Agenda in …

The contribution of genetic and environmental effects to Bergmann's rule and Allen's rule in house mice

MA Ballinger, MW Nachman - The American Naturalist, 2022 - journals.uchicago.edu
Distinguishing between genetic, environmental, and genotype× environment effects is
central to understanding geographic variation in phenotypic clines. Two of the best …

The influence of climate and population structure on East Asian skeletal morphology

EO Cho, LW Cowgill, KM Middleton… - Journal of Human …, 2022 - Elsevier
Recent studies have shown that global variation in body proportions is more complex than
previously thought as some traits formerly associated with climate adaptation are better …