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Effectiveness of zebrafish models in understanding human diseases—A review of models
Understanding the detailed mechanism behind every human disease, disorder, defect, and
deficiency is a daunting task concerning the clinical diagnostic tools for patients. Hence, a …
deficiency is a daunting task concerning the clinical diagnostic tools for patients. Hence, a …
Zebrafish patient avatars in cancer biology and precision cancer therapy
In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …
relevant tumour behaviours, such as treatment response and emergence of drug resistance …
Hooked! Modeling human disease in zebrafish
Zebrafish have been widely used as a model system for studying developmental processes,
but in the last decade, they have also emerged as a valuable system for modeling human …
but in the last decade, they have also emerged as a valuable system for modeling human …
The varied roles of notch in cancer
Notch receptors influence cellular behavior by participating in a seemingly simple signaling
pathway, but outcomes produced by Notch signaling are remarkably varied depending on …
pathway, but outcomes produced by Notch signaling are remarkably varied depending on …
Animal models of human disease: zebrafish swim into view
Despite the pre-eminence of the mouse in modelling human disease, several aspects of
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …
The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is a highly proliferative hematologic malignancy
that results from the transformation of immature T-cell progenitors. Aberrant cell growth and …
that results from the transformation of immature T-cell progenitors. Aberrant cell growth and …
[HTML][HTML] Zebrafish models of cancer—new insights on modeling human cancer in a non-mammalian vertebrate
Zebrafish (Danio rerio) is a valuable non-mammalian vertebrate model widely used to study
development and disease, including more recently cancer. The evolutionary conservation of …
development and disease, including more recently cancer. The evolutionary conservation of …
Acute lymphoblastic leukaemia
Acute lymphoblastic leukaemia, a malignant disorder of lymphoid progenitor cells, affects
both children and adults, with peak prevalence between the ages of 2 and 5 years. Steady …
both children and adults, with peak prevalence between the ages of 2 and 5 years. Steady …
Zebrafish cancer: the state of the art and the path forward
The zebrafish is a recent addition to animal models of human cancer, and studies using this
model are rapidly contributing major insights. Zebrafish develop cancer spontaneously, after …
model are rapidly contributing major insights. Zebrafish develop cancer spontaneously, after …
In vivo drug discovery in the zebrafish
The zebrafish has become a widely used model organism because of its fecundity, its
morphological and physiological similarity to mammals, the existence of many genomic tools …
morphological and physiological similarity to mammals, the existence of many genomic tools …