Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …

Homeostasis of multicellular organisms is critically dependent on the correct interpretation of
the plethora of signals which cells are exposed to during their lifespan. Various soluble …

The PTEN tumor suppressor was discovered by its homozygous deletion and other
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …

The biological and biochemical effects of estrogen have been ascribed to its known
receptors, which function as ligand-inducible transcription factors. However, estrogen also …

Communication between different cellular signaling systems has emerged as a common
principle that enables cells to integrate a multitude of signals from its environment …

SHP2 was recently found to down-regulate PI3K activation by dephosphorylating Gab1 but
the mechanisms explaining the positive role of the Gab1/SHP2 pathway in EGF-induced …

Over the last few years, many reports have extended our knowledge of the inositol lipid
metabolism and brought out some exciting information about the location, the variety and the …

The Grb2‐associated binder (Gab) family adapter proteins are scaffolding adapter
molecules that display sequence similarity with Drosophila DOS (daughter of sevenless) …

Gab proteins, including mammalian Gab1, Gab2, Gab3, Drosophila DOS and
Caenorhabditis elegans Soc1, comprise a growing family of scaffolding/docking molecules …

T to be appreciated. Here, we show that lysophosphatidic acid (LPA) stimulates the
production of PtdIns-3-P through activation of a class II PI3K (PI3K-C2). Both PtdIns-3-P and …