Quinoxaline: An insight into the recent pharmacological advances
S Tariq, K Somakala, M Amir - European Journal of Medicinal Chemistry, 2018 - Elsevier
Quinoxaline, a fused heterocycle of benzene and pyrazine rings has gained considerable
attention in the field of contemporary medicinal chemistry. The moiety is of substantial …
attention in the field of contemporary medicinal chemistry. The moiety is of substantial …
Introducing the antibacterial and photocatalytic degradation potentials of biosynthesized chitosan, chitosan–ZnO, and chitosan–ZnO/PVP nanoparticles
A Aouadi, D Hamada Saud, A Rebiai, A Achouri… - Scientific Reports, 2024 - nature.com
The development of nanomaterials has been speedily established in recent years, yet
nanoparticles synthesized by traditional methods suffer unacceptable toxicity and the …
nanoparticles synthesized by traditional methods suffer unacceptable toxicity and the …
In vitro and computational investigations of novel synthetic carboxamide-linked pyridopyrrolopyrimidines with potent activity as SARS-CoV-2-M Pro inhibitors
An essential target for COVID-19 is the main protease of SARS-CoV-2 (Mpro). With the
objective of targeting this receptor, a novel set of pyrido [1, 2-a] pyrrolo [2, 3-d] pyrimidines …
objective of targeting this receptor, a novel set of pyrido [1, 2-a] pyrrolo [2, 3-d] pyrimidines …
Apoptosis induction, PARP-1 inhibition, and cell cycle analysis of leukemia cancer cells treated with novel synthetic 1, 2, 3-triazole-chalcone conjugates
Leukemia is a life-threatening nonepithelial malignant disorder that is characterized by
uncontrolled growth of the hematopoietic cells. To date, there are still unmet needs for …
uncontrolled growth of the hematopoietic cells. To date, there are still unmet needs for …
From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity
Inhibition of PCAF bromodomain has been validated as a promising strategy for the
treatment of cancer. In this study, we report the bioisosteric modification of the first reported …
treatment of cancer. In this study, we report the bioisosteric modification of the first reported …
The antimicrobial potential and pharmacokinetic profiles of novel quinoline-based scaffolds: synthesis and in silico mechanistic studies as dual DNA gyrase and …
MH El-Shershaby, KM El-Gamal, AH Bayoumi… - New Journal of …, 2021 - pubs.rsc.org
The resistance of pathogenic microbes to currently available antimicrobial agents has been
considered a global alarming concern. Hence, close attention should be paid to the …
considered a global alarming concern. Hence, close attention should be paid to the …
Phenylpyrazolone-1, 2, 3-triazole hybrids as potent antiviral agents with promising SARS-CoV-2 main protease inhibition potential
COVID-19 infection is now considered one of the leading causes of human death. As an
attempt towards the discovery of novel medications for the COVID-19 pandemic, nineteen …
attempt towards the discovery of novel medications for the COVID-19 pandemic, nineteen …
The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico …
Abstract Treatment options for the management of breast cancer are still inadequate. This
inadequacy is attributed to the lack of effective targeted medications, often resulting in the …
inadequacy is attributed to the lack of effective targeted medications, often resulting in the …
Rationale design, synthesis, cytotoxicity evaluation, and in silico mechanistic studies of novel 1, 2, 3-triazoles with potential anticancer activity
A new set of 1, 2, 3-triazoles was designed and synthesized to evaluate their potential to
inhibit the growth of cancer cells. Thiazole, thiazolone, and hydrazine as effective fragments …
inhibit the growth of cancer cells. Thiazole, thiazolone, and hydrazine as effective fragments …
1, 2, 4-Triazolo [4, 3-c] quinazolines: a bioisosterism-guided approach towards the development of novel PCAF inhibitors with potential anticancer activity
Targeting PCAF with small inhibitor molecules has emerged as a potential therapeutic
strategy for the treatment of cancer. Recently, L-45 was identified as a potent …
strategy for the treatment of cancer. Recently, L-45 was identified as a potent …