Increasing evidence underlines that prototypical inflammatory cytokines (IL-1β, TNF-α and IL-
6) either synthesized in the central (CNS) or peripheral nervous system (PNS) by resident …

Critical illness polyneuropathies (CIP) and myopathies (CIM) are common complications of
critical illness. Several weakness syndromes are summarized under the term intensive care …

Tumor necrosis factor alpha (TNF-α) was discovered more than a century ago, and its known
roles have extended from within the immune system to include a neuro-inflammatory domain …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Objectives: We conducted a systematic review of the literature with meta-analysis to
determine whether complex regional pain syndrome (CRPS) is associated with a specific …

Background The dorsal root ganglion (DRG), in the not too distant past, had been thought of
as a passive organ not involved in the development of abnormal aberrent neuropathic pain …

Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory cytokine. It is generally
believed that TNF-α exerts its effects primarily via TNF receptor subtype-1 (TNFR1). We …

Migraine is the third most common disease worldwide, the most common neurological
disorder, and one of the most common pain conditions. Despite its prevalence, the basic …

Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …

The neuroimmune mechanism underlying neuropathic pain has been extensively studied.
Tumor necrosis factor-alpha (TNF-α), a key pro-inflammatory cytokine that drives cytokine …