Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …

Targeted protein degradation is a promising area in the discovery and development of
innovative therapeutics. Molecular glues mediate proximity-induced protein degradation and …

Biomolecular condensates concentrate macromolecules into discrete cellular foci without an
encapsulating membrane. Condensates are often presumed to increase enzymatic reaction …

Targeted protein degradation via “hijacking” of the ubiquitin-proteasome system using
proteolysis targeting chimeras (PROTACs) has evolved into a novel therapeutic modality …

Inflammasome complexes are pivotal in the innate immune response. The NLR family pyrin
domain containing protein 3 (NLRP3) inflammasome is activated in response to a broad …

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that belongs to the
phosphoinositide 3-kinase (PI3K)-related kinase (PIKK) family. The kinase exists in the …

Molecular chameleons possess a flexibility that allows them to dynamically shield or expose
polar functionalities in response to the properties of the environment. Although the concept …

The mechanistic target of rapamycin complex 1 (mTORC1) controls cell growth and
metabolism in response to nutrients, energy levels, and growth factors. It contains the …

Mammalian target of rapamycin complex 1 (mTORC1) monitors cellular amino acid changes
for function, but the molecular mediators of this process remain to be fully defined. Here, we …

Mammalian target of rapamycin (mTOR) is a highly conserved Serine/Threonine (Ser/Thr)
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …